gene gene gene gene gene gene gene gene gene gene gene gene ENSG_ALS2 Q96Q42 Alsin gene ENSG_ANG P03950 Angiogenin gene ENSG_ANXA11 P50995 Annexin A11 gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_ATXN2 Q99700 Ataxin-2 gene gene gene gene gene gene gene gene gene gene gene gene ENSG_C9orf72 Q96LT7 Guanine nucleotide exchange factor C9orf72 gene gene gene gene gene gene gene gene ENSG_CCNF P41002 Cyclin-F gene gene gene gene gene gene ENSG_CFAP410 O43822 Cilia- and flagella-associated protein 410 gene gene ENSG_CHCHD10 Q8WYQ3 Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial gene gene gene gene gene gene gene gene ENSG_CHMP2B Q9UQN3 Charged multivesicular body protein 2b gene gene gene gene gene gene gene gene gene gene gene gene ENSG_CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD gene gene ENSG_DAO P14920 D-amino-acid oxidase gene gene ENSG_DCTN1 Q14203 Dynactin subunit 1 gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_ELP3 Q9H9T3 Elongator complex protein 3 gene gene gene gene gene gene ENSG_ERBB4 Q15303 Receptor tyrosine-protein kinase erbB-4 gene gene gene gene gene gene ENSG_FGGY Q96C11 FGGY carbohydrate kinase domain-containing protein gene ENSG_FIG4 Q92562 Polyphosphoinositide phosphatase gene gene ENSG_FUS P35637 RNA-binding protein FUS gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_KIF5A Q12840 Kinesin heavy chain isoform 5A gene gene gene gene gene gene gene gene gene ENSG_LRP12 Q9Y561 Low-density lipoprotein receptor-related protein 12 gene gene gene gene gene gene gene ENSG_MATR3 P43243 Matrin-3 gene gene gene gene gene gene gene gene ENSG_MOBP Q13875 Myelin-associated oligodendrocyte basic protein gene gene gene gene gene gene gene gene gene gene gene gene ENSG_NEFH P12036 Neurofilament heavy polypeptide gene gene gene ENSG_NEK1 Q96PY6 Serine/threonine-protein kinase Nek1 gene gene gene gene gene gene gene gene gene gene gene ENSG_OPTN Q96CV9 Optineurin gene gene gene gene gene gene gene gene gene gene gene gene ENSG_PFN1 P07737 Profilin-1 gene gene gene gene gene gene gene gene gene gene gene gene ENSG_PRPH P41219 Peripherin gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_SCFD1 Q8WVM8 Sec1 family domain-containing protein 1 gene gene gene ENSG_SETX Q7Z333 Helicase senataxin gene gene gene gene gene gene ENSG_SIGMAR1 Q99720 Sigma non-opioid intracellular receptor 1 gene gene gene gene gene gene gene ENSG_SOD1 P00441 Superoxide dismutase [Cu-Zn] gene gene gene gene gene ENSG_SPG11 Q96JI7 Spatacsin gene gene gene ENSG_SPTLC1 O15269 Serine palmitoyltransferase 1 gene gene gene gene gene gene ENSG_SQSTM1 Q13501 Sequestosome-1 gene gene gene gene gene gene gene gene gene ENSG_TAF15 Q92804 TATA-binding protein-associated factor 2N gene gene gene gene gene ENSG_TARDBP Q13148 TAR DNA-binding protein 43 gene ENSG_TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 gene gene gene gene ENSG_TIA1 P31483 Cytotoxic granule associated RNA binding protein TIA1 gene gene ENSG_TMEM106B Q9NUM4 Transmembrane protein 106B gene gene gene gene gene gene gene gene gene gene gene gene ENSG_TRPM7 Q96QT4 Transient receptor potential cation channel subfamily M member 7 gene gene gene gene ENSG_TUBA4A P68366 Tubulin alpha-4A chain gene gene gene gene gene gene gene gene gene gene gene gene gene ENSG_UBQLN2 Q9UHD9 Ubiquilin-2 gene ENSG_UBQLN4 Q9NRR5 Ubiquilin-4 gene gene gene gene gene ENSG_UNC13A Q9UPW8 Protein unc-13 homolog A gene gene gene gene gene ENSG_VAPB O95292 Vesicle-associated membrane protein-associated protein B/C gene gene gene ENSG_VCP P55072 Transitional endoplasmic reticulum ATPase gene gene gene gene gene gene gene gene gene gene gene variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign ALS2-related disorder variant Likely pathogenic Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Likely pathogenic ALS2-related disorder variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance ALS2-related disorder variant Pathogenic Amyotrophic lateral sclerosis type 2, juvenile variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely pathogenic Infantile-onset ascending hereditary spastic paralysis variant Benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Amyotrophic lateral sclerosis type 2, juvenile variant Benign/Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Amyotrophic lateral sclerosis type 2, juvenile variant Likely pathogenic Amyotrophic lateral sclerosis type 2, juvenile variant Uncertain significance Amyotrophic lateral sclerosis type 2, juvenile variant Uncertain significance not provided variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Pathogenic Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely benign Infantile-onset ascending hereditary spastic paralysis variant Likely pathogenic Infantile-onset ascending hereditary spastic paralysis variant Uncertain significance not provided variant Conflicting classifications of pathogenicity not provided variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Conflicting classifications of pathogenicity not specified variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Conflicting classifications of pathogenicity not specified variant Likely pathogenic Amyotrophic lateral sclerosis type 9 variant Conflicting classifications of pathogenicity ANG-related disorder variant Pathogenic Amyotrophic lateral sclerosis type 9 variant Uncertain significance not provided variant Benign/Likely benign Inborn genetic diseases variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Benign not provided variant Benign not provided variant Benign not provided variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Benign Amyotrophic lateral sclerosis type 9 variant Benign Amyotrophic lateral sclerosis type 9 variant Benign Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Benign not provided variant Benign Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Benign not provided variant Likely benign Amyotrophic lateral sclerosis type 9 variant Benign/Likely benign not provided variant Benign Amyotrophic lateral sclerosis type 9 variant Benign/Likely benign Amyotrophic lateral sclerosis type 9 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 9 variant Likely benign Amyotrophic lateral sclerosis type 9 variant Likely benign Amyotrophic lateral sclerosis type 9 variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance not specified variant Uncertain significance not provided variant Uncertain significance not provided variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Likely benign Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Benign/Likely benign Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 9 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Likely benign not provided variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 23 variant Benign/Likely benign Amyotrophic lateral sclerosis type 23 variant Benign/Likely benign not provided variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance ANXA11-related disorder variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Pathogenic Amyotrophic lateral sclerosis type 23 variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Uncertain significance Amyotrophic lateral sclerosis type 23 variant Pathogenic not provided variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis variant Uncertain significance not provided variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis type 23 variant risk factor Amyotrophic lateral sclerosis, susceptibility to, 13 variant Likely pathogenic; risk factor Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Pathogenic Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign/Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Benign not provided variant Benign not provided variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign not provided variant Benign not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Pathogenic/Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant no classifications from unflagged records Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Inborn genetic diseases variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Likely benign not specified variant Likely benign Inborn genetic diseases variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Inborn genetic diseases variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance not provided variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign not provided variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Inborn genetic diseases variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Autosomal dominant mitochondrial myopathy with exercise intolerance variant Likely benign Autosomal dominant mitochondrial myopathy with exercise intolerance variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Uncertain significance Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Likely benign Lower motor neuron syndrome with late-adult onset variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign not specified variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign CHMP2B-related disorder variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance CHMP2B-related disorder variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign not specified variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign not provided variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance not specified variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance not provided variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign not specified variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Inborn genetic diseases variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance not specified variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Pathogenic Brooke-Spiegler syndrome variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Pathogenic/Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Familial cylindromatosis variant Uncertain significance Familial cylindromatosis variant Uncertain significance Familial cylindromatosis variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance not specified variant Pathogenic/Likely pathogenic Familial cylindromatosis variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance DAO-related disorder variant Uncertain significance DAO-related disorder variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Inborn genetic diseases variant Likely pathogenic Neuronopathy, distal hereditary motor, type 7B variant Uncertain significance Perry syndrome variant Likely benign not specified variant Uncertain significance Inborn genetic diseases variant Uncertain significance Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Benign not provided variant Benign not specified variant Benign Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance Intellectual disability variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance ERBB4-related disorder variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 19 variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not specified variant Uncertain significance not provided variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Likely pathogenic Amyotrophic lateral sclerosis type 19 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 19 variant Uncertain significance not provided variant Uncertain significance not provided variant Pathogenic not provided variant Conflicting classifications of pathogenicity not provided variant Benign not specified variant Conflicting classifications of pathogenicity not provided variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Likely pathogenic Amyotrophic lateral sclerosis variant Uncertain significance not provided variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Likely pathogenic Amyotrophic lateral sclerosis type 11 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Likely pathogenic Amyotrophic lateral sclerosis type 11 variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Pathogenic Amyotrophic lateral sclerosis type 11 variant Pathogenic Charcot-Marie-Tooth disease type 4 variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Uncertain significance Inborn genetic diseases variant Pathogenic Charcot-Marie-Tooth disease type 4 variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Inborn genetic diseases variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Benign/Likely benign not specified variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease variant Benign Charcot-Marie-Tooth disease variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease variant Benign Charcot-Marie-Tooth disease variant Benign/Likely benign Bilateral parasagittal parieto-occipital polymicrogyria variant Benign/Likely benign Charcot-Marie-Tooth disease variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Inborn genetic diseases variant Likely pathogenic not provided variant Likely pathogenic Charcot-Marie-Tooth disease type 4J variant Benign/Likely benign Charcot-Marie-Tooth disease type 4J variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Benign Charcot-Marie-Tooth disease type 4J variant Benign Charcot-Marie-Tooth disease type 4J variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Benign/Likely benign Inborn genetic diseases variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4J variant Pathogenic Charcot-Marie-Tooth disease type 4 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 11 variant Benign/Likely benign Inborn genetic diseases variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 11 variant Pathogenic/Likely pathogenic not provided variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease variant Uncertain significance Inborn genetic diseases variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Benign not provided variant Benign Charcot-Marie-Tooth disease type 4J variant Benign Charcot-Marie-Tooth disease type 4J variant Conflicting classifications of pathogenicity not specified variant Likely pathogenic Amyotrophic lateral sclerosis type 11 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Conflicting classifications of pathogenicity Bilateral parasagittal parieto-occipital polymicrogyria variant Uncertain significance not specified variant Pathogenic Charcot-Marie-Tooth disease type 4 variant Pathogenic/Likely pathogenic Yunis-Varon syndrome variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Uncertain significance Inborn genetic diseases variant Uncertain significance Inborn genetic diseases variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Benign Yunis-Varon syndrome variant Benign Charcot-Marie-Tooth disease type 4 variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease type 4 variant Pathogenic/Likely pathogenic Charcot-Marie-Tooth disease variant Uncertain significance Bilateral parasagittal parieto-occipital polymicrogyria variant Uncertain significance Charcot-Marie-Tooth disease type 4 variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 11 variant Uncertain significance Charcot-Marie-Tooth disease type 4J variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Uncertain significance Charcot-Marie-Tooth disease variant Uncertain significance Inborn genetic diseases variant Uncertain significance Amyotrophic lateral sclerosis type 11 variant Pathogenic Amyotrophic lateral sclerosis type 11 variant Likely benign Charcot-Marie-Tooth disease variant Benign/Likely benign Charcot-Marie-Tooth disease variant Benign not provided variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Pathogenic Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Tremor, hereditary essential, 4 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Tremor, hereditary essential, 4 variant Uncertain significance Tremor, hereditary essential, 4 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Conflicting classifications of pathogenicity not provided variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Pathogenic Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Pathogenic Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Tremor, hereditary essential, 4 variant Uncertain significance Tremor, hereditary essential, 4 variant Uncertain significance not provided variant Likely pathogenic Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Pathogenic Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Tremor, hereditary essential, 4 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign not specified variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Pathogenic/Likely pathogenic Tremor, hereditary essential, 4 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Likely benign Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis type 6 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Likely benign Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 variant Uncertain significance Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 variant Uncertain significance Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 variant Uncertain significance Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 variant Uncertain significance not provided variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely pathogenic Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 variant Likely pathogenic not provided variant Likely pathogenic not provided variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 25 variant Conflicting classifications of pathogenicity Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Pathogenic Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Likely benign Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 25 variant Uncertain significance Spastic paraplegia variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Pathogenic Spastic paraplegia variant Benign/Likely benign Amyotrophic lateral sclerosis, susceptibility to, 25 variant Uncertain significance Spastic paraplegia variant Conflicting classifications of pathogenicity Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Conflicting classifications of pathogenicity not provided variant Likely pathogenic not provided variant Uncertain significance Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Pathogenic Spastic paraplegia variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 25 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis, susceptibility to, 25 variant Pathogenic/Likely pathogenic Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Pathogenic Spastic paraplegia variant Uncertain significance Myoclonus, intractable, neonatal variant Uncertain significance Spastic paraplegia variant Pathogenic Spastic paraplegia variant risk factor Amyotrophic lateral sclerosis, susceptibility to, 25 variant Pathogenic/Likely pathogenic Spastic paraplegia variant Pathogenic/Likely pathogenic Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Benign/Likely benign Myoclonus, intractable, neonatal variant Likely pathogenic Spastic paraplegia variant Conflicting classifications of pathogenicity Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Uncertain significance Spastic paraplegia variant Conflicting classifications of pathogenicity Spastic paraplegia variant Conflicting classifications of pathogenicity Oculopharyngodistal myopathy 1 variant Uncertain significance Oculopharyngodistal myopathy 1 variant Pathogenic Oculopharyngodistal myopathy 1 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign not specified variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Likely benign Amyotrophic lateral sclerosis type 21 variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Inborn genetic diseases variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Inborn genetic diseases variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Conflicting classifications of pathogenicity not provided variant Conflicting classifications of pathogenicity Charcot-Marie-Tooth disease axonal type 2CC variant risk factor Amyotrophic lateral sclerosis, susceptibility to variant Uncertain significance Inborn genetic diseases variant Uncertain significance Inborn genetic diseases variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not specified variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance not provided variant Uncertain significance not provided variant Benign Charcot-Marie-Tooth disease axonal type 2CC variant Benign Charcot-Marie-Tooth disease axonal type 2CC variant Benign/Likely benign not provided variant Benign Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Benign not specified variant Benign Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 1 variant Benign not specified variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Benign Charcot-Marie-Tooth disease axonal type 2CC variant Benign Charcot-Marie-Tooth disease axonal type 2CC variant Benign/Likely benign not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely benign not provided variant Uncertain significance not provided variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance NEK1-related disorder variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Conflicting classifications of pathogenicity Motor neuron disease variant Uncertain significance NEK1-related disorder variant Pathogenic/Likely pathogenic Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant other Motor neuron disease variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis, susceptibility to, 24 variant Conflicting classifications of pathogenicity Motor neuron disease variant Pathogenic; other Short-rib thoracic dysplasia 6 with or without polydactyly variant Pathogenic; other Motor neuron disease variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Conflicting classifications of pathogenicity Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic Short-rib thoracic dysplasia 6 with or without polydactyly variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis, susceptibility to, 24 variant Benign/Likely benign Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Likely pathogenic not provided variant Pathogenic/Likely pathogenic NEK1-related disorder variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Amyotrophic lateral sclerosis variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Conflicting classifications of pathogenicity Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Mohr syndrome variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Pathogenic Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Pathogenic not provided variant Conflicting classifications of pathogenicity Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic not provided variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Likely pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Pathogenic Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Amyotrophic lateral sclerosis variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant risk factor Amyotrophic lateral sclerosis, susceptibility to, 24 variant Pathogenic Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Conflicting classifications of pathogenicity not provided variant Likely benign Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Amyotrophic lateral sclerosis, susceptibility to, 24 variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Inborn genetic diseases variant Uncertain significance Amyotrophic lateral sclerosis variant Likely pathogenic Short-rib thoracic dysplasia 6 with or without polydactyly variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Pathogenic Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Pathogenic Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Pathogenic Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely benign Amyotrophic lateral sclerosis type 12 variant Uncertain significance not provided variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely benign Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Pathogenic Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely pathogenic Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Conflicting classifications of pathogenicity not provided variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Pathogenic Primary open angle glaucoma variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Likely benign Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Likely benign Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Pathogenic Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Likely benign Glaucoma 1, open angle, E variant Pathogenic Glaucoma 1, open angle, E variant Uncertain significance Glaucoma 1, open angle, E variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely benign Amyotrophic lateral sclerosis type 12 variant Likely benign Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Inborn genetic diseases variant Likely pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Pathogenic Amyotrophic lateral sclerosis type 12 variant Uncertain significance Amyotrophic lateral sclerosis type 12 variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Primary open angle glaucoma variant Benign Primary open angle glaucoma variant Likely benign Primary open angle glaucoma variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not provided variant Likely pathogenic Amyotrophic lateral sclerosis type 18 variant Uncertain significance PFN1-related disorder variant Benign/Likely benign not provided variant Benign not specified variant Uncertain significance not provided variant Pathogenic not provided variant Pathogenic not provided variant Pathogenic not provided variant Conflicting classifications of pathogenicity not specified variant Conflicting classifications of pathogenicity not specified variant Uncertain significance Amyotrophic lateral sclerosis variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance not specified variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Benign not specified variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant risk factor Amyotrophic lateral sclerosis, susceptibility to variant Benign not provided variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity Inborn genetic diseases variant Uncertain significance not provided variant Benign/Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Benign Amyotrophic lateral sclerosis type 4 variant Benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Likely benign Amyotrophic lateral sclerosis type 4 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Pathogenic Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Likely benign Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 variant Uncertain significance Inborn genetic diseases variant Uncertain significance Inborn genetic diseases variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Pathogenic Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely pathogenic Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Pathogenic Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Autosomal recessive distal spinal muscular atrophy 2 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Pathogenic Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Pathogenic Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Pathogenic Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Pathogenic Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Pathogenic Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Likely benign Autosomal recessive distal spinal muscular atrophy 2 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely pathogenic Amyotrophic lateral sclerosis type 16 variant Likely pathogenic Amyotrophic lateral sclerosis type 16 variant Likely pathogenic Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 16 variant Uncertain significance Amyotrophic lateral sclerosis type 16 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely benign not provided variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Pathogenic not provided variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 1 variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely pathogenic not provided variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Inborn genetic diseases variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity not provided variant Conflicting classifications of pathogenicity Spastic tetraplegia and axial hypotonia, progressive variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance not provided variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Pathogenic SOD1-related disorder variant Uncertain significance SOD1-related disorder variant Likely pathogenic SOD1-related disorder variant Uncertain significance not provided variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic not provided variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance Amyotrophic lateral sclerosis type 1 variant Likely benign Amyotrophic lateral sclerosis type 1 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 5 variant Uncertain significance Hereditary spastic paraplegia 11 variant Likely benign Amyotrophic lateral sclerosis type 5 variant Likely benign Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Charcot-Marie-Tooth disease axonal type 2X variant Uncertain significance Hereditary spastic paraplegia 11 variant Uncertain significance Inborn genetic diseases variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Conflicting classifications of pathogenicity Hereditary spastic paraplegia 11 variant Uncertain significance Hereditary spastic paraplegia variant Uncertain significance Hereditary spastic paraplegia 11 variant Uncertain significance Hereditary spastic paraplegia 11 variant Conflicting classifications of pathogenicity Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Conflicting classifications of pathogenicity not provided variant Pathogenic/Likely pathogenic Abnormal central motor function variant Likely benign not provided variant Benign/Likely benign Hereditary spastic paraplegia 11 variant Uncertain significance Charcot-Marie-Tooth disease axonal type 2X variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Charcot-Marie-Tooth disease axonal type 2X variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Charcot-Marie-Tooth disease axonal type 2X variant Uncertain significance not provided variant Uncertain significance Hereditary spastic paraplegia 11 variant Uncertain significance Charcot-Marie-Tooth disease axonal type 2X variant Pathogenic/Likely pathogenic Charcot-Marie-Tooth disease axonal type 2X variant Uncertain significance Hereditary spastic paraplegia 11 variant Pathogenic/Likely pathogenic Inborn genetic diseases variant Uncertain significance Hereditary spastic paraplegia 11 variant Uncertain significance Hereditary spastic paraplegia 11 variant Likely benign Hereditary spastic paraplegia 11 variant Uncertain significance Hereditary spastic paraplegia 11 variant Uncertain significance Inborn genetic diseases variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Charcot-Marie-Tooth disease axonal type 2X variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Uncertain significance not provided variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic/Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Hereditary spastic paraplegia 11 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Uncertain significance Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Likely pathogenic Amyotrophic lateral sclerosis type 5 variant Conflicting classifications of pathogenicity not provided variant Pathogenic Amyotrophic lateral sclerosis 27, juvenile variant Pathogenic Neuropathy, hereditary sensory and autonomic, type 1A variant Uncertain significance Hereditary sensory and autonomic neuropathy type 1 variant Uncertain significance Amyotrophic lateral sclerosis 27, juvenile variant Uncertain significance Amyotrophic lateral sclerosis 27, juvenile variant Pathogenic not provided variant Uncertain significance Neuropathy, hereditary sensory and autonomic, type 1A variant Uncertain significance Amyotrophic lateral sclerosis 27, juvenile variant Uncertain significance Neuropathy, hereditary sensory and autonomic, type 1A variant Likely pathogenic Neuropathy, hereditary sensory and autonomic, type 1A variant Pathogenic/Likely pathogenic Amyotrophic lateral sclerosis 27, juvenile variant Uncertain significance Hereditary sensory and autonomic neuropathy type 1 variant Uncertain significance Hereditary sensory and autonomic neuropathy type 1 variant Uncertain significance Hereditary sensory and autonomic neuropathy type 1 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis 27, juvenile variant Pathogenic/Likely pathogenic Proximal lower limb amyotrophy variant Uncertain significance Hereditary sensory and autonomic neuropathy type 1 variant Likely pathogenic Amyotrophic lateral sclerosis variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Inborn genetic diseases variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Paget disease of bone 3 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance not provided variant Uncertain significance TAF15-related disorder variant Uncertain significance TAF15-related disorder variant Uncertain significance TAF15-related disorder variant Uncertain significance TAF15-related disorder variant Uncertain significance TAF15-related disorder variant Uncertain significance TAF15-related disorder variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis variant Conflicting classifications of pathogenicity not provided variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Inborn genetic diseases variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance not specified variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Benign/Likely benign Inborn genetic diseases variant Likely benign Inborn genetic diseases variant Uncertain significance Inborn genetic diseases variant Conflicting classifications of pathogenicity not provided variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Pathogenic Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Inborn genetic diseases variant Likely pathogenic Amyotrophic lateral sclerosis type 10 variant Likely benign Inborn genetic diseases variant Benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance not specified variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely pathogenic Amyotrophic lateral sclerosis type 10 variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Likely benign FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely benign Amyotrophic lateral sclerosis type 10 variant Uncertain significance Inclusion body myositis variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Conflicting classifications of pathogenicity Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Inborn genetic diseases variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance not provided variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Pathogenic Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 variant Conflicting classifications of pathogenicity Welander distal myopathy variant Uncertain significance not provided variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia variant Uncertain significance Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia variant Uncertain significance Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia variant Uncertain significance Welander distal myopathy variant Uncertain significance Welander distal myopathy variant Uncertain significance not provided variant Conflicting classifications of pathogenicity not provided variant Uncertain significance Welander distal myopathy variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance not specified variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance not specified variant Uncertain significance not specified variant Conflicting classifications of pathogenicity Juvenile amyotrophic lateral sclerosis variant Benign Amyotrophic lateral sclerosis-parkinsonism-dementia complex variant Uncertain significance Amyotrophic lateral sclerosis variant Uncertain significance Amyotrophic lateral sclerosis type 10 variant Likely pathogenic not provided variant Pathogenic Amyotrophic lateral sclerosis type 22 variant Pathogenic Amyotrophic lateral sclerosis type 22 variant Uncertain significance not provided variant Likely pathogenic Amyotrophic lateral sclerosis type 22 variant Pathogenic Amyotrophic lateral sclerosis type 22 variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Conflicting classifications of pathogenicity not provided variant Likely pathogenic Amyotrophic lateral sclerosis type 22 variant Likely benign not specified variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Uncertain significance Ptosis variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Uncertain significance Amyotrophic lateral sclerosis type 22 variant Pathogenic Amyotrophic lateral sclerosis type 22 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Conflicting classifications of pathogenicity not specified variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance not provided variant Likely pathogenic UBQLN2-related disorder variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 15 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Conflicting classifications of pathogenicity not specified variant Benign Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Conflicting classifications of pathogenicity Amyotrophic lateral sclerosis type 15 variant Uncertain significance not specified variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely pathogenic Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance not provided variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Conflicting classifications of pathogenicity not provided variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely benign Amyotrophic lateral sclerosis type 15 variant Uncertain significance Amyotrophic lateral sclerosis type 15 variant Likely pathogenic Amyotrophic lateral sclerosis type 1 variant Uncertain significance not provided variant Benign/Likely benign not provided variant Uncertain significance not provided variant Uncertain significance UNC13A-related disorder variant Conflicting classifications of pathogenicity not specified variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance not provided variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance not provided variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Amyotrophic lateral sclerosis type 8 variant Uncertain significance Amyotrophic lateral sclerosis type 8 variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Uncertain significance Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Adult-onset proximal spinal muscular atrophy, autosomal dominant variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Likely benign Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Uncertain significance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Pathogenic/Likely pathogenic Charcot-Marie-Tooth disease type 2Y variant Uncertain significance Inborn genetic diseases variant Likely pathogenic Inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1 variant Pathogenic not provided variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Uncertain significance Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia variant Likely benign Inclusion body myopathy with Paget disease of bone and frontotemporal dementia disease amyotrophic lateral sclerosis type 2, juvenile disease amyotrophic lateral sclerosis disease familial amyotrophic lateral sclerosis disease juvenile amyotrophic lateral sclerosis disease amyotrophic lateral sclerosis type 4 disease sporadic amyotrophic lateral sclerosis disease amyotrophic lateral sclerosis type 11 disease amyotrophic lateral sclerosis type 20 disease amyotrophic lateral sclerosis type 22 disease frontotemporal dementia and/or amyotrophic lateral sclerosis 6 disease amyotrophic lateral sclerosis type 18 disease frontotemporal dementia and/or amyotrophic lateral sclerosis 4 disease frontotemporal dementia and/or amyotrophic lateral sclerosis disease frontotemporal dementia and/or amyotrophic lateral sclerosis 1 disease amyotrophic lateral sclerosis, dominant disease amyotrophic lateral sclerosis 27, juvenile disease amyotrophic lateral sclerosis-parkinsonism-dementia complex disease amyotrophic lateral sclerosis type 15 disease amyotrophic lateral sclerosis 28 disease amyotrophic lateral sclerosis type 5 disease amyotrophic lateral sclerosis type 8 disease amyotrophic lateral sclerosis 26 with or without frontotemporal dementia pathway RAB GEFs exchange GTP for GDP on RABs pathway RAC1 GTPase cycle pathway Adherens junctions interactions pathway tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis pathway Neddylation pathway Antigen processing: Ubiquitination & Proteasome degradation pathway Mitochondrial protein import pathway Budding and maturation of HIV virion pathway Macroautophagy pathway Pyroptosis pathway Endosomal Sorting Complex Required For Transport (ESCRT) pathway HCMV Late Events pathway Late endosomal microautophagy pathway Sealing of the nuclear envelope (NE) by ESCRT-III pathway Translation of Replicase and Assembly of the Replication Transcription Complex pathway Translation of Replicase and Assembly of the Replication Transcription Complex pathway NOD1/2 Signaling Pathway pathway TNFR1-induced proapoptotic signaling pathway Regulation of TNFR1 signaling pathway TNFR1-induced NF-kappa-B signaling pathway pathway Ub-specific processing proteases pathway Negative regulators of DDX58/IFIH1 signaling pathway Glyoxylate metabolism and glycine degradation pathway Peroxisomal protein import pathway MHC class II antigen presentation pathway Regulation of PLK1 Activity at G2/M Transition pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway Loss of Nlp from mitotic centrosomes pathway Recruitment of mitotic centrosome proteins and complexes pathway Loss of proteins required for interphase microtubule organization from the centrosome pathway Recruitment of NuMA to mitotic centrosomes pathway XBP1(S) activates chaperone genes pathway Anchoring of the basal body to the plasma membrane pathway COPI-mediated anterograde transport pathway COPI-independent Golgi-to-ER retrograde traffic pathway AURKA Activation by TPX2 pathway Signaling by ALK fusions and activated point mutants pathway HATs acetylate histones pathway Signaling by ERBB2 pathway Signaling by ERBB4 pathway SHC1 events in ERBB2 signaling pathway PI3K events in ERBB4 signaling pathway SHC1 events in ERBB4 signaling pathway Nuclear signaling by ERBB4 pathway Downregulation of ERBB4 signaling pathway PIP3 activates AKT signaling pathway GRB2 events in ERBB2 signaling pathway PI3K events in ERBB2 signaling pathway Constitutive Signaling by Aberrant PI3K in Cancer pathway RAF/MAP kinase cascade pathway ERBB2 Regulates Cell Motility pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling pathway ERBB2 Activates PTK6 Signaling pathway Downregulation of ERBB2 signaling pathway Estrogen-dependent gene expression pathway Long-term potentiation pathway Signaling by ERBB2 KD Mutants pathway Signaling by ERBB2 TMD/JMD mutants pathway Synthesis of PIPs at the Golgi membrane pathway Synthesis of PIPs at the early endosome membrane pathway Synthesis of PIPs at the late endosome membrane pathway mRNA Splicing - Major Pathway pathway Processing of Capped Intron-Containing Pre-mRNA pathway mRNA Polyadenylation pathway Dengue Virus-Host Interactions pathway FGFR2 alternative splicing pathway SARS-CoV-1-host interactions pathway SARS-CoV-1 modulates host translation machinery pathway Insulin processing pathway RHO GTPases activate KTN1 pathway COPI-dependent Golgi-to-ER retrograde traffic pathway Kinesins pathway Retinoid metabolism and transport pathway Transcriptional Regulation by MECP2 pathway Regulation of pyruvate metabolism pathway PINK1-PRKN Mediated Mitophagy pathway TBC/RABGAPs pathway TICAM1-dependent activation of IRF3/IRF7 pathway Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 pathway Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation pathway Platelet degranulation pathway Signaling by ROBO receptors pathway PCP/CE pathway pathway RHO GTPases Activate Formins pathway COPII-mediated vesicle transport pathway RHOA GTPase cycle pathway Potential therapeutics for SARS pathway Detoxification of Reactive Oxygen Species pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation pathway Sphingolipid de novo biosynthesis pathway NRIF signals cell death from the nucleus pathway p75NTR recruits signalling complexes pathway NF-kB is activated and signals survival pathway Interleukin-1 signaling pathway Pexophagy pathway KEAP1-NFE2L2 pathway pathway Nuclear events mediated by NFE2L2 pathway HIV Transcription Initiation pathway RNA Polymerase II HIV Promoter Escape pathway Transcription of the HIV genome pathway RNA Polymerase II Pre-transcription Events pathway Regulation of TP53 Activity through Phosphorylation pathway RNA Polymerase II Promoter Escape pathway RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway RNA Polymerase II Transcription Initiation pathway RNA Polymerase II Transcription Initiation And Promoter Clearance pathway IRF3 mediated activation of type 1 IFN pathway DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway Regulation of innate immune responses to cytosolic DNA pathway STAT6-mediated induction of chemokines pathway IRF3-mediated induction of type I IFN pathway Interleukin-37 signaling pathway TRAF3-dependent IRF activation pathway pathway TRAF6 mediated IRF7 activation pathway SARS-CoV-1 activates/modulates innate immune responses pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses pathway TRP channels pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway Gap junction assembly pathway Separation of Sister Chromatids pathway Resolution of Sister Chromatid Cohesion pathway Prefoldin mediated transfer of substrate to CCT/TriC pathway Formation of tubulin folding intermediates by CCT/TriC pathway Post-chaperonin tubulin folding pathway pathway Recycling pathway of L1 pathway Hedgehog 'off' state pathway Cargo trafficking to the periciliary membrane pathway Intraflagellar transport pathway RHO GTPases activate IQGAPs pathway Mitotic Prometaphase pathway The role of GTSE1 in G2/M progression after G2 checkpoint pathway Carboxyterminal post-translational modifications of tubulin pathway HCMV Early Events pathway Assembly and cell surface presentation of NMDA receptors pathway Activation of AMPK downstream of NMDARs pathway Aggrephagy pathway EML4 and NUDC in mitotic spindle formation pathway PKR-mediated signaling pathway Cargo recognition for clathrin-mediated endocytosis pathway RHOC GTPase cycle pathway RAC2 GTPase cycle pathway RHOD GTPase cycle pathway RHOG GTPase cycle pathway Translesion Synthesis by POLH pathway HSF1 activation pathway ABC-family protein mediated transport pathway N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway Hedgehog ligand biogenesis pathway Hh mutants are degraded by ERAD pathway Defective CFTR causes cystic fibrosis pathway Josephin domain DUBs pathway Ovarian tumor domain proteases pathway Neutrophil degranulation pathway E3 ubiquitin ligases ubiquitinate target proteins pathway Protein methylation pathway RHOH GTPase cycle pathway Attachment and Entry pathway Attachment and Entry pathway Dengue Virus Genome Translation and Replication pathway AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide paper 10.1073/pnas.0505149102 A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. 2005 Aug 9 paper 10.1016/j.bbadis.2007.02.008 TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD? 2007 Aug paper 10.1093/hmg/ddn375 Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. 2009 Feb 1 paper 10.1093/hmg/ddp059 A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. 2009 Apr 15 paper 10.1002/ajmg.b.30966 TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. 2010 Jan 5 paper 10.1016/j.neurobiolaging.2009.04.018 No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort. 2011 Mar paper 10.3109/17482960802673042 Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. 2009 Oct-Dec paper 10.3109/17482960903278451 Multiple neurotoxic items in the Chamorro diet link BMAA with ALS/PDC. 2009 paper 10.3109/17482960903358857 Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis. 2010 Aug paper 10.1371/journal.pgen.1000820 The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. 2010 Jan 22 paper CHMP2B-Related Frontotemporal Dementia-Amyotrophic Lateral Sclerosis. 1993 paper Amyotrophic Lateral Sclerosis Overview. 1993 paper 10.1007/s10048-010-0239-4 RNA processing pathways in amyotrophic lateral sclerosis. 2010 Jul paper 10.1111/j.1471-4159.2010.06892.x The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila. 2010 Oct paper 10.1007/978-94-007-0265-3_9 TRPM7, the Mg(2+) inhibited channel and kinase. 2011 paper 10.1371/journal.pone.0017477 Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation. 2011 Mar 7 paper 10.1371/journal.pone.0032768 A high-density genome-wide association screen of sporadic ALS in US veterans. 2012 paper 10.1016/j.nbd.2013.08.006 Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice. 2013 Dec paper 10.1016/j.neurobiolaging.2013.12.018 Single-nucleotide polymorphism rs6690993 in FGGY is not associated with amyotrophic lateral sclerosisin a large Chinese cohort. 2014 Jun paper 10.1016/j.celrep.2014.05.051 HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release. 2014 Jul 10 paper 10.1016/j.neurobiolaging.2014.12.032 The distinct genetic pattern of ALS in Turkey and novel mutations. 2015 Apr paper 10.1038/ng.3622 Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 2016 Sep paper 10.7554/elife.25453 A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis. 2017 May 2 paper 10.1007/s11356-017-0450-z Multivariate curve resolution of organic pollution patterns in mangrove forest sediment from Qeshm Island and Khamir Port-Persian Gulf, Iran. 2018 Jan paper 10.1093/hmg/ddy043 Elongator subunit 3 (ELP3) modifies ALS through tRNA modification. 2018 Apr 1 paper 10.3389/fimmu.2018.01287 Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin. 2018 paper 10.1016/j.brainres.2018.10.032 MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS). 2019 Mar 1 paper 10.1016/j.nbd.2018.11.025 Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics. 2019 Apr paper 10.1038/s41556-019-0281-x Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. 2019 Mar paper 10.1111/neup.12564 Immunoreactivity of myelin-associated oligodendrocytic basic protein in Lewy bodies. 2019 Aug paper SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson's disease. 2016 paper 10.1038/s41588-019-0458-z Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease. 2019 Aug paper 10.1038/s41397-019-0111-3 Pharmacogenetic interactions in amyotrophic lateral sclerosis: a step closer to a cure? 2020 Apr paper 10.1093/brain/awaa039 CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. 2020 Mar 1 paper 10.1615/critreveukaryotgeneexpr.2020031020 Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights. 2020 paper 10.1007/s00415-020-10042-y Targeted next-generation sequencing study in familial ALS-FTD Portuguese patients negative for C9orf72 HRE. 2020 Dec paper 10.1093/braincomms/fcaa124 Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses. 2020 paper 10.3389/fncel.2020.594975 The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS. 2020 paper 10.3390/cells9122687 Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis. 2020 Dec 15 paper 10.1002/pro.4108 Electrostatic modulation of hnRNPA1 low-complexity domain liquid-liquid phase separation and aggregation. 2021 Jul paper 10.1080/15548627.2021.1943177 The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy. 2022 Mar paper 10.1096/fj.202100137r Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis. 2021 Jul paper 10.1002/acn3.51419 Evaluation of peripherin in biofluids of patients with motor neuron diseases. 2021 Aug paper 10.1038/s41598-021-94225-1 Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis. 2021 Jul 21 paper 10.1016/j.scr.2021.102520 Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. 2021 Oct paper 10.1136/jmedgenet-2021-107883 NOTCH2NLC-related disorders: the widening spectrum and genotype-phenotype correlation. 2022 Jan paper 10.1111/ane.13538 Myelin-associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease. 2022 Feb paper 10.3389/fgene.2021.740052 Rare CYLD Variants in Chinese Patients With Amyotrophic Lateral Sclerosis. 2021 paper 10.3390/medicina57121337 MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study. 2021 Dec 7 paper 10.1007/s12640-021-00465-4 The Cyanotoxin 2,4-DAB Reduces Viability and Causes Behavioral and Molecular Dysfunctions Associated with Neurodegeneration in Larval Zebrafish. 2022 Apr paper 10.1089/neu.2021.0338 Suppression of Transient Receptor Potential Melastatin 7 by Carvacrol Protects against Injured Spinal Cord by Inhibiting Blood-Spinal Cord Barrier Disruption. 2022 May paper 10.1007/s00018-022-04170-z RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. 2022 Mar 5 paper 10.1080/15548627.2022.2063003 Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine. 2023 Jan paper 10.1016/j.expneurol.2022.114143 Multiple roles for the cytoskeleton in ALS. 2022 Sep paper 10.1111/jnc.15682 The 2022 Lady Estelle Wolfson lectureship on neurofilaments. 2022 Nov paper 10.1002/acn3.51655 CYLD variants identified in Alzheimer's disease and frontotemporal dementia patients. 2022 Oct paper 10.3389/fnmol.2022.954928 A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression. 2022 paper 10.1007/s13760-022-02148-z Novel compound heterozygous variants of SPG11 gene associated with young-adult amyotrophic lateral sclerosis. 2023 Aug paper 10.3390/ijms232314769 Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies. 2022 Nov 25 paper 10.1016/j.neurobiolaging.2022.11.011 Genetic landscape of ALS in Malta based on a quinquennial analysis. 2023 Mar paper 10.1101/2023.01.25.525508 Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1. 2023 Jan 25 paper 10.1016/j.biopsych.2022.11.002 Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood. 2023 May 1 paper 10.1016/j.neurobiolaging.2023.02.005 Loss of amyotrophic lateral sclerosis risk factor SCFD1 causes motor dysfunction in Drosophila. 2023 Jun paper 10.3390/ijms24065828 In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis. 2023 Mar 18 paper 10.1007/s00415-023-11746-7 Genetic characterization of primary lateral sclerosis. 2023 Aug paper 10.1007/s00415-023-11757-4 Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data. 2023 Aug paper 10.1111/ene.15855 Advantages of routine next-generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic. 2023 Aug paper 10.14336/ad.2022.12209 Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease. 2023 Aug 1 paper 10.26508/lsa.202201740 Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases. 2023 Jul paper 10.1007/s12035-023-03355-2 The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis. 2023 Sep paper 10.3389/fnins.2023.1170996 Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy. 2023 paper 10.1038/s41467-023-39274-y Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. 2023 Jun 13 paper 10.1016/j.ajhg.2023.05.014 CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis. 2023 Jul 6 paper 10.1016/j.bbalip.2023.159359 SPTLC1 p.Leu38Arg, a novel mutation associated with childhood ALS. 2023 Sep paper 10.1016/j.jmgm.2023.108572 Structural dynamics of moonlighting intrinsically disordered proteins - A black box in multiple sclerosis. 2023 Nov paper 10.1159/000530974 Thirty-Year Follow-Up of Early Onset Amyotrophic Lateral Sclerosis with a Pathogenic Variant in SPTLC1. 2023 Jan-Dec paper 10.1016/j.bbapap.2023.140947 Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis. 2023 Nov 1 paper 10.3390/neurolint15030063 FTD/ALS Type 7-Associated Thr104Asn Mutation of CHMP2B Blunts Neuronal Process Elongation, and Is Recovered by Knockdown of Arf4, the Golgi Stress Regulator. 2023 Aug 11 paper 10.12688/f1000research.139755.1 The identification of high-performing antibodies for Charged multivesicular body protein 2b for use in Western Blot, immunoprecipitation and immunofluorescence. 2023 paper 10.1007/s12035-023-03587-2 Abnormal Brain Protein Abundance and Cross-tissue mRNA Expression in Amyotrophic Lateral Sclerosis. 2024 Jan paper 10.1186/s40035-023-00375-9 Research progress on the role of extracellular vesicles in neurodegenerative diseases. 2023 Sep 11 paper 10.3389/fneur.2023.1242472 SIGMAR1 variants in ALS-PD complex cases: a case report of a novel mutation and literature review. 2023 paper 10.2174/1567205020666230811092906 Behavioural Variant Frontotemporal Dementia due to CCNF Gene Mutation: A Case Report. 2023 paper 10.4103/1673-5374.386411 SCFD1 in amyotrophic lateral sclerosis: reconciling a genetic association with in vivo functional analysis. 2024 Jun 1 paper 10.1016/j.neurobiolaging.2023.09.017 Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis. 2024 Feb paper 10.1038/s41598-023-46802-9 ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation. 2023 Nov 22 paper 10.1016/j.ijbiomac.2023.128403 Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase. 2024 Jan paper 10.1136/jnnp-2023-331753 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10.1002/biof.2037 Deciphering the role of Zn(2+)-binding histidines from TIA-1 on the assembly and dynamics of stress granules. 2024 Jul-Aug paper 10.3389/fnins.2023.1300705 Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. 2023 paper 10.1248/bpb.b23-00828 Wild-Type DCTN1 Suppresses the Aggregation of DCTN1 Mutants Associated with Perry Disease. 2024 paper 10.1186/s40478-024-01729-8 Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. 2024 Feb 4 paper 10.1002/acn3.52013 SPTLC2 variants are associated with early-onset ALS and FTD due to aberrant sphingolipid synthesis. 2024 Apr paper 10.3390/cimb46020090 Modulating Golgi Stress Signaling Ameliorates Cell Morphological Phenotypes Induced by CHMP2B with Frontotemporal Dementia-Associated p.Asp148Tyr. 2024 Feb 5 paper 10.1080/21678421.2024.2324896 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high-performing antibodies for Optineurin (UniProt ID: Q96CV9) for use in western blot, immunoprecipitation, and immunofluorescence. 2025 paper 10.64898/2026.02.11.705390 TRIM32-UBQLN2-p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates. 2026 Feb 13 paper 10.1136/bmjno-2025-001417 Bi-allelic intermediate ATXN2 repeat expansions are associated with slow progressing, leg-onset familial ALS. 2026 paper 10.1016/j.isci.2026.114879 FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS-FTD-associated CHCHD10(S59L) in Drosophila and human cells. 2026 Mar 20 paper 10.1080/21678421.2026.2630882 Clinical characterization of the proximal lower-limb ALS phenotype: a retrospective cohort study. 2026 Feb 24 paper 10.2147/dnnd.s568971 Genetic Spectrum and Phenotypic Variability in Chinese Patients with Multisystem Proteinopathy and Related Disorders. 2026 paper 10.3390/brainsci16020144 Enlarged Perivascular Spaces (EPVS) and the Risk of Amyotrophic Lateral Sclerosis (ALS): Evidence for Overlapping Genetic Signals in White Matter Without Causal Links. 2026 Jan 28 paper 10.21203/rs.3.rs-8380062/v1 Reversing Mitochondrial Dysfunction in Optineurin E50K Glaucoma: A Metabolic Approach to Neuroprotection. 2026 Feb 19 paper 10.1007/s10072-026-08885-w KIF5A and ALS: a clinical and genetic description of a case series and review of literature. 2026 Feb 28 paper 10.1097/cnd.0000000000000556 Respiratory Onset Amyotrophic Lateral Sclerosis in a Patient With C9orf72 Expansion. 2026 Mar 1 paper 10.1016/j.clineuro.2026.109381 Pathogenic VCP (p.Arg453Trp) variant in three siblings with frontotemporal dementia-amyotrophic lateral sclerosis spectrum: A Turkish family. 2026 Jun paper 10.1016/j.talanta.2026.129603 A multi-platform analytical strategy for Atractylodes lancea authentication: Fusion of stable isotope, elemental, chromatographic, and spectroscopic profiles. 2026 Aug 1 paper 10.1080/27694127.2026.2638025 Kenny is the adaptor protein for ubiquitin-dependent mitophagy in Drosophila melanogaster. 2026 paper 10.1111/febs.70487 Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset. 2026 Mar 10 paper 10.1016/j.neuron.2026.02.003 Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes. 2026 Jun 17 paper 10.3390/cells15050420 TIA1 Mutant Mouse Model Exhibits Motor Deficits and Neurodegenerative Characteristics of Amyotrophic Lateral Sclerosis. 2026 Feb 27 paper 10.3390/cells15050477 TBK1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Mechanistic Insights into Impaired Autophagy and Proteostatic Failure. 2026 Mar 6 paper 10.1016/j.freeradbiomed.2026.03.037 Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression. 2026 Jun paper 10.3389/fgene.2026.1774170 Functional validation of the novel KIF5A p.R17Q VUS reveals defective axonal transport in iPSC-motoneurons from a SPG10 patient. 2026 paper 10.1212/nxg.0000000000200362 Consequences of the Novel ALS-Associated KIF5A Variant c.2993-6C > A for Exon 27 Splicing and Axonal Transport of SFPQ. 2026 Apr paper 10.1002/1873-3468.70328 Valosin-containing protein counteracts ATP-driven dissolution of FUS condensates through its ATPase activity in vitro. 2026 Mar 16 paper 10.1038/s44318-026-00745-9 ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences. 2026 Apr paper 10.1212/nxg.0000000000200369 The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study and Literature Review. 2026 Apr paper 10.1172/jci.insight.197941 KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS. 2026 May 22 paper 10.64898/2026.03.06.710113 A mouse model of autosomal dominant spastic ataxia and myopathy caused by a mutation in Tuba4a. 2026 Mar 9 paper 10.1093/brain/awag115 Clinical and biochemical characterization of amyotrophic lateral sclerosis in a CHCHD10 R15L family. 2026 Mar 30 paper 10.1016/j.ijbiomac.2026.151719 Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS. 2026 Apr paper 10.1038/s41593-026-02226-y UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration. 2026 Apr paper 10.1038/s41588-026-02535-9 Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis. 2026 Apr paper 10.1002/brb3.71366 Integrative Multi-Omics Mendelian Randomization Highlights Causal Autophagy-Related Genes for Amyotrophic Lateral Sclerosis. 2026 Apr paper 10.64898/2026.03.25.714147 Cross-disease genetic and epigenetic architecture of the MOBP locus shows convergence in ALS-PSP. 2026 Mar 27 paper 10.1212/wnl.0000000000214858 Long-Term Exposure to Ambient Air Pollution and Incident Amyotrophic Lateral Sclerosis: A Prospective Cohort Analysis of the UK Biobank. 2026 Apr 28 paper 10.1016/j.nedt.2026.107094 Effects of distinct prebriefing and debriefing on learning outcomes in advanced life support training for ward nurses: A randomized controlled trial. 2026 Aug paper 10.1016/j.bbrc.2026.153723 Decoding RNA splicing pathology: Alternative splicing in amyotrophic lateral sclerosis and its therapeutic potential. 2026 Jun 18 paper 10.64898/2026.04.16.718620 The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP. 2026 May 4 paper 10.3390/cells15080699 Astro-Versus Microglia-Enriched Transcriptomes from Aged Atxn2-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies. 2026 Apr 15 paper 10.1016/j.jare.2026.04.066 Physiological and pathological functions of TAF15 in neurodegenerative diseases and cancers. 2026 Apr 26 paper 10.1186/s12974-026-03827-x ALS-FTD-linked CCNF(S621G) drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability. 2026 May 2 paper 10.1007/s12311-026-02011-4 Unraveling the Pathophysiological Link Between ALS and SCA: The Role of Ischemic Cerebral Vascular Dissection and the Efficacy of Endovascular Therapy. 2026 May 4 paper 10.1186/s40478-026-02301-2 Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis. 2026 May 5 paper 10.64898/2026.04.23.719939 TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain. 2026 Apr 27 paper 10.1038/s42003-026-10226-8 Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline. 2026 May 8 paper 10.2147/jir.s585872 Integrative Transcriptomics Identifies Ubiquitination-Related Genes BIRC2, COPS5, and TBK1 as Novel Biomarkers of T-Cell Dysregulation in Amyotrophic Lateral Sclerosis. 2026 paper 10.1038/s41419-026-08830-x A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system. 2026 May 14 paper 10.1007/s00415-026-13848-4 Associations of cognitive and behavioural impairment in ALS with brain pathology: pTDP-43 versus microglial activation. 2026 May 15 paper 10.1038/s41419-026-08856-1 VCP modulation ameliorates pathological features in C9orf72 models. 2026 May 17 paper 10.64898/2026.04.29.26350889 The New York Genome Center ALS Consortium resource integrates postmortem tissue transcriptomics and whole genome sequencing to empower biological discovery. 2026 May 4 paper 10.1080/21678421.2026.2674020 Clinical characterization and natural history of ALS8/VAPB p.Pro56Ser: upper motor neurone signs, survival, and functional milestones in 78 patients. 2026 May 21 paper 10.1111/cge.70185 Expanding Spectrum of FIG4-Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype-Phenotype Correlations. 2026 May 22 paper 10.1021/acschemneuro.6c00226 Kinetics and Spatial Distribution of β-Sheet Development in TDP-43(CTD) Condensate Maturation. 2026 Jun 3 paper 10.1007/s11064-026-04770-2 TDP-43 Acetylation at the Neuroimmune Interface: A Hypothesis-Driven Framework for Peripheral Inflammatory Stratotypes in ALS. 2026 May 22 paper 10.1002/advs.202516846 Protein Disulfide Isomerase Disassembles TDP-43/G3BP1 Condensates and Antagonizes TDP-43 Pathological Aggregates. 2026 May 25 paper 10.1080/15548627.2026.2678427 CHCHD2 and CHCHD10 promoted autophagic clearance of protein aggregates via GABARAPs. 2026 May 25 paper 10.3390/jof12050341 RNA-Binding Protein TAF15 Suppresses Toxicity in a Yeast Model of FUS Proteinopathy. 2026 May 6 paper 10.3390/genes17050576 From Mutation to Manifestation: Penetrance in Amyotrophic Lateral Sclerosis. 2026 May 18 paper 10.1016/j.celrep.2026.117430 RNA-binding protein diversity and NLS arginines regulate FUS mixing in mRNA-rich compartments. 2026 May 28 paper 10.1186/s40478-026-02298-8 VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. 2026 May 29 paper 10.1172/jci191508 Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression. 2026 Jun 1 paper 10.1111/ene.70653 Distinct UNC13A Haplotype Blocks Define Disease Severity and Survival in Chinese Amyotrophic Lateral Sclerosis. 2026 Jun paper 10.1021/jacs.6c07727 Site-Specific Raman Probes Reveal Droplet Aging and Residue-Level Fibril Polymorphism in TDP-43(CTD). 2026 Jun 17 paper 10.1007/s13577-026-01399-9 FUS modulates R-loops by functionally interacting with RNase H1. 2026 Jun 2 paper 10.1242/dmm.052810 Fos regulates age-dependent neuroinflammation in VAPBALS. 2026 Jun 4 paper 10.64898/2026.05.21.727000 The retroelement-derived human protein PEG10 is a regulator of mRNA splicing in neurons. 2026 May 24 paper 10.64898/2026.05.16.725609 Chronic diazepam reveals excessive homeostatic gain in SOD1(G93A) mouse spinal motoneurons. 2026 May 19 paper 10.1007/s12035-026-05979-6 Synaptic Plasticity Changes in the Somatosensory Cortex During Amyotrophic Lateral Sclerosis Progression and After Swim Training in SOD1-G93A Mice. 2026 Jun 4 paper 10.1016/j.nbd.2026.107467 Early-onset neuroinflammation drives neurodegeneration caused by lysosomal PI(3,5)P(2) insufficiency. 2026 Aug paper 10.1186/s13020-026-01433-w Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS. 2026 Jun 4 paper 10.1016/j.ijbiomac.2026.152922 Inhibitory effect of silymarin on amyloid formation in ALS-associated hSOD1 P66R mutant. 2026 Jun 5 paper 10.1186/s13024-026-00959-9 RAN translation as a dominant pathogenic axis in C9ORF72-associated ALS and FTD models. 2026 Jun 6 paper 10.1016/j.nbd.2026.107473 PBMC DEG/miRNA biomarkers of TDP-43 pathology in ALS. 2026 Aug paper 10.3389/fnagi.2026.1831861 NEK1 variants and reduced protein levels in Chinese ALS patients: a descriptive study. 2026 paper 10.3389/fnmol.2026.1864964 Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review. 2026 paper 10.1093/braincomms/fcag208 Correction to: C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia. 2026 paper 10.1080/15548627.2026.2686417 PFN1 inhibits lytic replication of Kaposi sarcoma-associated herpesvirus through SQSTM1/p62-mediated selective autophagy targeting the KSHV helicase. 2026 Jun 14 paper 10.2174/011570159x462214260429080002 The Pivotal Role of HDAC6 in Amyotrophic Lateral Sclerosis: Neuroprotective Protagonist or Degenerative Adversary? 2026 Jun 8 paper 10.1016/j.celrep.2026.117326 Human J-domain proteins promote stress granule disassembly and suppress neurodegeneration-linked protein aggregation. 2026 Jun 8 paper 10.1002/mus.70314 Two Patients With Juvenile-Onset, Rapidly Progressive Amyotrophic Lateral Sclerosis Associated With an SOD1 Variant (p.Asp125Gly) With Incomplete Penetrance. 2026 Jun 9 paper 10.1007/s00415-026-13929-4 FUS-associated ALS in Taiwan: genetic spectrum, clinical features, and a founder haplotype of p.H517D. 2026 Jun 10 paper 10.1080/21678421.2026.2685158 Oligogenic variants in NEK1 and ATXN2 in amyotrophic lateral sclerosis: report of two cases and review of the literature. 2026 Jun 10 paper 10.64898/2026.05.30.729013 PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse model. 2026 Jun 3 paper 10.1002/mus.70310 Optimizing Research Operations and Resource Utilization in ALS Care: Insights From the Tofersen Antisense Oligonucleotide Expanded Access Protocol. 2026 Jun 12 paper 10.1016/j.biopha.2026.119622 Focused ultrasound-mediated nanocarrier delivery across the blood-brain barrier for neurodegenerative diseases. 2026 Jun 13 paper 10.1038/s41597-026-07626-0 Quantitative Proteomics Unveils Comprehensive Tissue-Specific VCP Interaction Networks in Mice. 2026 Jun 13 paper 10.1002/acn3.70447 Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis. 2026 Jun 15 paper 10.1080/21678421.2026.2663910 Innate immune signaling as a potential pathomechanistic biomarker for distinct subtypes in amyotrophic lateral sclerosis. 2026 Jun 15 paper 10.2174/0118715273440191260226063811 Pathogenic Proteins Driving ALS Pathogenesis: Molecular Mechanisms and Translational Therapeutic Perspectives. 2026 Apr 1 paper 10.1002/mus.70320 Amyotrophic Lateral Sclerosis Recovery: A New Model System of Care Integrating Neuromuscular Rehabilitation With Clinical Stabilization in ALS. 2026 Jun 16 paper 10.1016/j.chembiol.2026.05.009 S-acylation of TDP-43: PALMing down aggregation? 2026 Jun 18 paper 10.1016/j.ijbiomac.2026.153101 Folding pathways and force-induced unfolding of neurodegeneration associated GGGGCC microsatellite repeat RNA revealed by molecular simulations. 2026 Jun 18 paper 10.1136/bmjopen-2025-110906 Strategic Amyotrophic Lateral Sclerosis Australia-Systems Genomics Consortium (SALSA-SGC): cohort profile. 2026 Jun 18 paper 10.1186/s40478-026-02341-8 Intrathecal (G(4)C(2))(149) delivery in C9orf72-deficient mice yields mild motor dysfunction and ALS/FTD pathological hallmarks. 2026 Jun 18 paper 10.1111/febs.70630 PML as a neuroprotective guardian: Leveraging nuclear protein quality control to mitigate neurotoxicity of an ALS-associated NEK1 variant. 2026 Jun 19 hypothesis Shared pathway convergence of CCNF and SQSTM1 in Neddylation Both CCNF and SQSTM1 participate in the pathway Neddylation (R-HSA-8951664), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CHMP2B and TUBA4A in Sealing of the nuclear envelope (NE) by ESCRT-III Both CHMP2B and TUBA4A participate in the pathway Sealing of the nuclear envelope (NE) by ESCRT-III (R-HSA-9668328), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and OPTN in TNFR1-induced proapoptotic signaling Both CYLD and OPTN participate in the pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and OPTN in Regulation of TNFR1 signaling Both CYLD and OPTN participate in the pathway Regulation of TNFR1 signaling (R-HSA-5357905), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and OPTN in TNFR1-induced NF-kappa-B signaling pathway Both CYLD and OPTN participate in the pathway TNFR1-induced NF-kappa-B signaling pathway (R-HSA-5357956), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and TBK1 in Negative regulators of DDX58/IFIH1 signaling Both CYLD and TBK1 participate in the pathway Negative regulators of DDX58/IFIH1 signaling (R-HSA-936440), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of DCTN1 and KIF5A in MHC class II antigen presentation Both DCTN1 and KIF5A participate in the pathway MHC class II antigen presentation (R-HSA-2132295), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and OPTN in Regulation of PLK1 Activity at G2/M Transition Both DCTN1 and OPTN participate in the pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Both DCTN1 and TUBA4A participate in the pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (R-HSA-3371497), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Loss of Nlp from mitotic centrosomes Both DCTN1 and TUBA4A participate in the pathway Loss of Nlp from mitotic centrosomes (R-HSA-380259), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Recruitment of mitotic centrosome proteins and complexes Both DCTN1 and TUBA4A participate in the pathway Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Loss of proteins required for interphase microtubule organization from the centrosome Both DCTN1 and TUBA4A participate in the pathway Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Recruitment of NuMA to mitotic centrosomes Both DCTN1 and TUBA4A participate in the pathway Recruitment of NuMA to mitotic centrosomes (R-HSA-380320), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Anchoring of the basal body to the plasma membrane Both DCTN1 and TUBA4A participate in the pathway Anchoring of the basal body to the plasma membrane (R-HSA-5620912), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in COPI-mediated anterograde transport Both DCTN1 and TUBA4A participate in the pathway COPI-mediated anterograde transport (R-HSA-6807878), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in COPI-independent Golgi-to-ER retrograde traffic Both DCTN1 and TUBA4A participate in the pathway COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in AURKA Activation by TPX2 Both DCTN1 and TUBA4A participate in the pathway AURKA Activation by TPX2 (R-HSA-8854518), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and SQSTM1 in Signaling by ALK fusions and activated point mutants Both DCTN1 and SQSTM1 participate in the pathway Signaling by ALK fusions and activated point mutants (R-HSA-9725370), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of FUS and HNRNPA1 in mRNA Splicing - Major Pathway Both FUS and HNRNPA1 participate in the pathway mRNA Splicing - Major Pathway (R-HSA-72163), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of FUS and HNRNPA1 in Processing of Capped Intron-Containing Pre-mRNA Both FUS and HNRNPA1 participate in the pathway Processing of Capped Intron-Containing Pre-mRNA (R-HSA-72203), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of FUS and HNRNPA1 in mRNA Polyadenylation Both FUS and HNRNPA1 participate in the pathway mRNA Polyadenylation (R-HSA-9770562), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of FUS and HNRNPA1 in Dengue Virus-Host Interactions Both FUS and HNRNPA1 participate in the pathway Dengue Virus-Host Interactions (R-HSA-9918481), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of HNRNPA1 and TIA1 in FGFR2 alternative splicing Both HNRNPA1 and TIA1 participate in the pathway FGFR2 alternative splicing (R-HSA-6803529), indicating a potential converged pathological mechanism. Medium candidate mechanism hypothesis Shared pathway convergence of KIF5A and TUBA4A in COPI-dependent Golgi-to-ER retrograde traffic Both KIF5A and TUBA4A participate in the pathway COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of KIF5A and TUBA4A in Kinesins Both KIF5A and TUBA4A participate in the pathway Kinesins (R-HSA-983189), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and SQSTM1 in PINK1-PRKN Mediated Mitophagy Both OPTN and SQSTM1 participate in the pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in TICAM1-dependent activation of IRF3/IRF7 Both OPTN and TBK1 participate in the pathway TICAM1-dependent activation of IRF3/IRF7 (R-HSA-9013973), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Both OPTN and TBK1 participate in the pathway Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (R-HSA-936964), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Both OPTN and TBK1 participate in the pathway Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (R-HSA-9824878), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Both OPTN and TBK1 participate in the pathway Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (R-HSA-9828211), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of PFN1 and SOD1 in Platelet degranulation Both PFN1 and SOD1 participate in the pathway Platelet degranulation (R-HSA-114608), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of PFN1 and TUBA4A in RHO GTPases Activate Formins Both PFN1 and TUBA4A participate in the pathway RHO GTPases Activate Formins (R-HSA-5663220), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of SCFD1 and VAPB in RHOA GTPase cycle Both SCFD1 and VAPB participate in the pathway RHOA GTPase cycle (R-HSA-8980692), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of SIGMAR1 and TBK1 in Potential therapeutics for SARS Both SIGMAR1 and TBK1 participate in the pathway Potential therapeutics for SARS (R-HSA-9679191), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of SPTLC1 and VAPB in Sphingolipid de novo biosynthesis Both SPTLC1 and VAPB participate in the pathway Sphingolipid de novo biosynthesis (R-HSA-1660661), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of SQSTM1 and VCP in KEAP1-NFE2L2 pathway Both SQSTM1 and VCP participate in the pathway KEAP1-NFE2L2 pathway (R-HSA-9755511), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of TUBA4A and VCP in Aggrephagy Both TUBA4A and VCP participate in the pathway Aggrephagy (R-HSA-9646399), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of SQSTM1 and VCP in Neddylation Both SQSTM1 and VCP participate in the pathway Neddylation (R-HSA-8951664), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in TNFR1-induced proapoptotic signaling Both OPTN and TBK1 participate in the pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TBK1 in Regulation of TNFR1 signaling Both OPTN and TBK1 participate in the pathway Regulation of TNFR1 signaling (R-HSA-5357905), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of KIF5A and TUBA4A in MHC class II antigen presentation Both KIF5A and TUBA4A participate in the pathway MHC class II antigen presentation (R-HSA-2132295), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of OPTN and TUBA4A in Regulation of PLK1 Activity at G2/M Transition Both OPTN and TUBA4A participate in the pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of SQSTM1 and TBK1 in PINK1-PRKN Mediated Mitophagy Both SQSTM1 and TBK1 participate in the pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of SOD1 and TUBA4A in Platelet degranulation Both SOD1 and TUBA4A participate in the pathway Platelet degranulation (R-HSA-114608), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CCNF and VCP in Neddylation Both CCNF and VCP participate in the pathway Neddylation (R-HSA-8951664), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and TBK1 in TNFR1-induced proapoptotic signaling Both CYLD and TBK1 participate in the pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of CYLD and TBK1 in Regulation of TNFR1 signaling Both CYLD and TBK1 participate in the pathway Regulation of TNFR1 signaling (R-HSA-5357905), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of DCTN1 and TUBA4A in MHC class II antigen presentation Both DCTN1 and TUBA4A participate in the pathway MHC class II antigen presentation (R-HSA-2132295), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of DCTN1 and TUBA4A in Regulation of PLK1 Activity at G2/M Transition Both DCTN1 and TUBA4A participate in the pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942), indicating a potential converged pathological mechanism. Low protective hypothesis Shared pathway convergence of OPTN and TBK1 in PINK1-PRKN Mediated Mitophagy Both OPTN and TBK1 participate in the pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Shared pathway convergence of PFN1 and TUBA4A in Platelet degranulation Both PFN1 and TUBA4A participate in the pathway Platelet degranulation (R-HSA-114608), indicating a potential converged pathological mechanism. Low candidate mechanism hypothesis Network-proximity association of candidate gene ATXN3 Candidate gene ATXN3 directly interacts with multiple ALS seed genes (ATXN2, VCP) with an average interaction confidence score of 0.996. Low candidate mechanism hypothesis Network-proximity association of candidate gene DERL1 Candidate gene DERL1 directly interacts with multiple ALS seed genes (SOD1, VCP) with an average interaction confidence score of 0.982. Low protective hypothesis Network-proximity association of candidate gene DESI1 Candidate gene DESI1 directly interacts with multiple ALS seed genes (UBQLN2, UBQLN4) with an average interaction confidence score of 0.996. Low candidate mechanism hypothesis Network-proximity association of candidate gene DROSHA Candidate gene DROSHA directly interacts with multiple ALS seed genes (FUS, TARDBP) with an average interaction confidence score of 0.992. Low candidate mechanism hypothesis Network-proximity association of candidate gene GABARAP Candidate gene GABARAP directly interacts with multiple ALS seed genes (OPTN, SQSTM1) with an average interaction confidence score of 0.999. Low candidate mechanism hypothesis Network-proximity association of candidate gene GABARAPL1 Candidate gene GABARAPL1 directly interacts with multiple ALS seed genes (OPTN, SQSTM1) with an average interaction confidence score of 0.998. Low candidate mechanism hypothesis Network-proximity association of candidate gene GABARAPL2 Candidate gene GABARAPL2 directly interacts with multiple ALS seed genes (OPTN, SQSTM1) with an average interaction confidence score of 0.998. Low candidate mechanism hypothesis Network-proximity association of candidate gene HNRNPA2B1 Candidate gene HNRNPA2B1 directly interacts with multiple ALS seed genes (FUS, HNRNPA1, TARDBP) with an average interaction confidence score of 0.995. Low protective hypothesis Network-proximity association of candidate gene HNRNPC Candidate gene HNRNPC directly interacts with multiple ALS seed genes (FUS, HNRNPA1, MATR3) with an average interaction confidence score of 0.974. Low candidate mechanism hypothesis Network-proximity association of candidate gene HNRNPH1 Candidate gene HNRNPH1 directly interacts with multiple ALS seed genes (HNRNPA1, MATR3) with an average interaction confidence score of 0.955. High candidate mechanism hypothesis Network-proximity association of candidate gene HNRNPK Candidate gene HNRNPK directly interacts with multiple ALS seed genes (HNRNPA1, MATR3) with an average interaction confidence score of 0.959. High candidate mechanism hypothesis Network-proximity association of candidate gene HNRNPM Candidate gene HNRNPM directly interacts with multiple ALS seed genes (HNRNPA1, MATR3) with an average interaction confidence score of 0.961. High candidate mechanism hypothesis Network-proximity association of candidate gene HSPA5 Candidate gene HSPA5 directly interacts with multiple ALS seed genes (SIGMAR1, SOD1) with an average interaction confidence score of 0.984. Low protective hypothesis Network-proximity association of candidate gene IKBKE Candidate gene IKBKE directly interacts with multiple ALS seed genes (CYLD, TBK1) with an average interaction confidence score of 0.996. Low candidate mechanism hypothesis Network-proximity association of candidate gene ITPR1 Candidate gene ITPR1 directly interacts with multiple ALS seed genes (ATXN2, SIGMAR1) with an average interaction confidence score of 0.967. Low protective hypothesis Network-proximity association of candidate gene KIF5B Candidate gene KIF5B directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.944. Low candidate mechanism hypothesis Network-proximity association of candidate gene KIF5C Candidate gene KIF5C directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.946. Low candidate mechanism hypothesis Network-proximity association of candidate gene KLC1 Candidate gene KLC1 directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.961. Low candidate mechanism hypothesis Network-proximity association of candidate gene KLC2 Candidate gene KLC2 directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.961. Low candidate mechanism hypothesis Network-proximity association of candidate gene KLC3 Candidate gene KLC3 directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.959. Low candidate mechanism hypothesis Network-proximity association of candidate gene KLC4 Candidate gene KLC4 directly interacts with multiple ALS seed genes (KIF5A, NEFH) with an average interaction confidence score of 0.957. Low candidate mechanism hypothesis Network-proximity association of candidate gene MAP1LC3B Candidate gene MAP1LC3B directly interacts with multiple ALS seed genes (OPTN, SQSTM1) with an average interaction confidence score of 0.998. Low candidate mechanism hypothesis Network-proximity association of candidate gene MAPT Candidate gene MAPT directly interacts with multiple ALS seed genes (TMEM106B, TUBA4A) with an average interaction confidence score of 0.865. Low candidate mechanism hypothesis Network-proximity association of candidate gene MATR3-2 Candidate gene MATR3-2 directly interacts with multiple ALS seed genes (TAF15, TARDBP) with an average interaction confidence score of 0.934. Low candidate mechanism hypothesis Network-proximity association of candidate gene NEFL Candidate gene NEFL directly interacts with multiple ALS seed genes (KIF5A, NEFH, PRPH, SOD1) with an average interaction confidence score of 0.956. Low candidate mechanism hypothesis Network-proximity association of candidate gene NEFM Candidate gene NEFM directly interacts with multiple ALS seed genes (KIF5A, NEFH, PRPH) with an average interaction confidence score of 0.944. Low candidate mechanism hypothesis Network-proximity association of candidate gene PABPC1 Candidate gene PABPC1 directly interacts with multiple ALS seed genes (ATXN2, TIA1) with an average interaction confidence score of 0.966. High candidate mechanism hypothesis Network-proximity association of candidate gene PSMD4 Candidate gene PSMD4 directly interacts with multiple ALS seed genes (UBQLN2, UBQLN4) with an average interaction confidence score of 0.990. Low candidate mechanism hypothesis Network-proximity association of candidate gene RAB8A Candidate gene RAB8A directly interacts with multiple ALS seed genes (C9orf72, OPTN) with an average interaction confidence score of 0.990. Low candidate mechanism hypothesis Network-proximity association of candidate gene RIPK1 Candidate gene RIPK1 directly interacts with multiple ALS seed genes (CYLD, SQSTM1) with an average interaction confidence score of 0.998. Low candidate mechanism hypothesis Network-proximity association of candidate gene SFPQ Candidate gene SFPQ directly interacts with multiple ALS seed genes (FUS, MATR3) with an average interaction confidence score of 0.980. Low candidate mechanism hypothesis Network-proximity association of candidate gene SNCA Candidate gene SNCA directly interacts with multiple ALS seed genes (KIF5A, TARDBP) with an average interaction confidence score of 0.959. Low protective hypothesis Network-proximity association of candidate gene TNPO1 Candidate gene TNPO1 directly interacts with multiple ALS seed genes (FUS, HNRNPA1) with an average interaction confidence score of 0.996. Low protective hypothesis Network-proximity association of candidate gene TRAF6 Candidate gene TRAF6 directly interacts with multiple ALS seed genes (CYLD, SQSTM1) with an average interaction confidence score of 0.999. Low candidate mechanism hypothesis Network-proximity association of candidate gene UBC Candidate gene UBC directly interacts with multiple ALS seed genes (CYLD, OPTN, SQSTM1, UBQLN2) with an average interaction confidence score of 0.997. Low candidate mechanism hypothesis Network-proximity association between ALS2 and RAB5A ALS2 interacts directly with RAB5A with a confidence score of 0.991, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and NEK1 ALS2 interacts directly with NEK1 with a confidence score of 0.942, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and SETX ALS2 interacts directly with SETX with a confidence score of 0.909, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and SOD1 ALS2 interacts directly with SOD1 with a confidence score of 0.891, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and GAPVD1 ALS2 interacts directly with GAPVD1 with a confidence score of 0.886, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and VAPB ALS2 interacts directly with VAPB with a confidence score of 0.879, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and CFAP410 ALS2 interacts directly with CFAP410 with a confidence score of 0.875, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and FIG4 ALS2 interacts directly with FIG4 with a confidence score of 0.854, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and TARDBP ALS2 interacts directly with TARDBP with a confidence score of 0.828, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ALS2 and FUS ALS2 interacts directly with FUS with a confidence score of 0.822, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ANG and RNH1 ANG interacts directly with RNH1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASE4 ANG interacts directly with RNASE4 with a confidence score of 0.988, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASE2 ANG interacts directly with RNASE2 with a confidence score of 0.926, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASE8 ANG interacts directly with RNASE8 with a confidence score of 0.901, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASE3 ANG interacts directly with RNASE3 with a confidence score of 0.879, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASET2 ANG interacts directly with RNASET2 with a confidence score of 0.829, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and PLXNB2 ANG interacts directly with PLXNB2 with a confidence score of 0.806, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and CXCL8 ANG interacts directly with CXCL8 with a confidence score of 0.767, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and RNASEL ANG interacts directly with RNASEL with a confidence score of 0.74, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANG and FST ANG interacts directly with FST with a confidence score of 0.711, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ANXA11 and S100A6 ANXA11 interacts directly with S100A6 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ANXA11 and ANXA7 ANXA11 interacts directly with ANXA7 with a confidence score of 0.92, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ANXA11 and PDCD6 ANXA11 interacts directly with PDCD6 with a confidence score of 0.889, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ANXA11 and BTNL2 ANXA11 interacts directly with BTNL2 with a confidence score of 0.841, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ANXA11 and TFG ANXA11 interacts directly with TFG with a confidence score of 0.7, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ATXN2 and PABPC1 ATXN2 interacts directly with PABPC1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and ITPR1 ATXN2 interacts directly with ITPR1 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and RBFOX1 ATXN2 interacts directly with RBFOX1 with a confidence score of 0.995, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and ATXN3 ATXN2 interacts directly with ATXN3 with a confidence score of 0.993, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and DDX6 ATXN2 interacts directly with DDX6 with a confidence score of 0.993, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and TARDBP ATXN2 interacts directly with TARDBP with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ATXN2 and LSM12 ATXN2 interacts directly with LSM12 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN1 and ATXN2 ATXN1 interacts directly with ATXN2 with a confidence score of 0.969, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and ATXN3L ATXN2 interacts directly with ATXN3L with a confidence score of 0.961, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ATXN2 and ATXN2L ATXN2 interacts directly with ATXN2L with a confidence score of 0.953, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between C9orf72 and WDR41 C9orf72 interacts directly with WDR41 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and SMCR8 C9orf72 interacts directly with SMCR8 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and ULK1 C9orf72 interacts directly with ULK1 with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and RAB1A C9orf72 interacts directly with RAB1A with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and RB1CC1 C9orf72 interacts directly with RB1CC1 with a confidence score of 0.983, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and RAB39B C9orf72 interacts directly with RAB39B with a confidence score of 0.983, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and RAB8A C9orf72 interacts directly with RAB8A with a confidence score of 0.98, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ATG101 and C9orf72 ATG101 interacts directly with C9orf72 with a confidence score of 0.979, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and TARDBP C9orf72 interacts directly with TARDBP with a confidence score of 0.943, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between C9orf72 and FUS C9orf72 interacts directly with FUS with a confidence score of 0.929, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CCNF and SKP1 CCNF interacts directly with SKP1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and CUL1 CCNF interacts directly with CUL1 with a confidence score of 0.986, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and CCP110 CCNF interacts directly with CCP110 with a confidence score of 0.984, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and SKP2 CCNF interacts directly with SKP2 with a confidence score of 0.946, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between BTRC and CCNF BTRC interacts directly with CCNF with a confidence score of 0.921, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and PLK1 CCNF interacts directly with PLK1 with a confidence score of 0.918, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and RBX1 CCNF interacts directly with RBX1 with a confidence score of 0.917, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and CDK1 CCNF interacts directly with CDK1 with a confidence score of 0.911, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and CDC20 CCNF interacts directly with CDC20 with a confidence score of 0.91, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CCNF and RRM2 CCNF interacts directly with RRM2 with a confidence score of 0.893, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CFAP410 and NEK1 CFAP410 interacts directly with NEK1 with a confidence score of 0.982, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CFAP410 and PFKL CFAP410 interacts directly with PFKL with a confidence score of 0.784, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between CFAP410 and MX1 CFAP410 interacts directly with MX1 with a confidence score of 0.773, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between CHCHD10 and CHCHD6 CHCHD10 interacts directly with CHCHD6 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and CHCHD3 CHCHD10 interacts directly with CHCHD3 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and IMMT CHCHD10 interacts directly with IMMT with a confidence score of 0.979, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and MICOS13 CHCHD10 interacts directly with MICOS13 with a confidence score of 0.978, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between APOO and CHCHD10 APOO interacts directly with CHCHD10 with a confidence score of 0.967, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between APOOL and CHCHD10 APOOL interacts directly with CHCHD10 with a confidence score of 0.965, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and CHCHD2 CHCHD10 interacts directly with CHCHD2 with a confidence score of 0.888, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and MICOS10 CHCHD10 interacts directly with MICOS10 with a confidence score of 0.875, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CHCHD10 and CHCHD4 CHCHD10 interacts directly with CHCHD4 with a confidence score of 0.816, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between CHCHD10 and MATR3 CHCHD10 interacts directly with MATR3 with a confidence score of 0.736, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between CHMP2B and VPS4B CHMP2B interacts directly with VPS4B with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and CHMP3 CHMP2B interacts directly with CHMP3 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP1A and CHMP2B CHMP1A interacts directly with CHMP2B with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP1B and CHMP2B CHMP1B interacts directly with CHMP2B with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and CHMP4A CHMP2B interacts directly with CHMP4A with a confidence score of 0.991, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and CHMP4B CHMP2B interacts directly with CHMP4B with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2A and CHMP2B CHMP2A interacts directly with CHMP2B with a confidence score of 0.987, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and VPS4A CHMP2B interacts directly with VPS4A with a confidence score of 0.986, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and CHMP6 CHMP2B interacts directly with CHMP6 with a confidence score of 0.978, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHMP2B and CHMP7 CHMP2B interacts directly with CHMP7 with a confidence score of 0.973, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CYLD and TRAF6 CYLD interacts directly with TRAF6 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and RIPK1 CYLD interacts directly with RIPK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and TNFRSF1A CYLD interacts directly with TNFRSF1A with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and IKBKG CYLD interacts directly with IKBKG with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and SPATA2 CYLD interacts directly with SPATA2 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and TRADD CYLD interacts directly with TRADD with a confidence score of 0.995, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and UBC CYLD interacts directly with UBC with a confidence score of 0.995, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and IKBKE CYLD interacts directly with IKBKE with a confidence score of 0.994, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and RNF31 CYLD interacts directly with RNF31 with a confidence score of 0.993, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CYLD and TRAF2 CYLD interacts directly with TRAF2 with a confidence score of 0.992, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and DAOA DAO interacts directly with DAOA with a confidence score of 0.987, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and GLDC DAO interacts directly with GLDC with a confidence score of 0.967, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and SARDH DAO interacts directly with SARDH with a confidence score of 0.966, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between AGXT and DAO AGXT interacts directly with DAO with a confidence score of 0.964, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and SHMT1 DAO interacts directly with SHMT1 with a confidence score of 0.962, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and SHMT2 DAO interacts directly with SHMT2 with a confidence score of 0.96, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and PIPOX DAO interacts directly with PIPOX with a confidence score of 0.952, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between AGXT2 and DAO AGXT2 interacts directly with DAO with a confidence score of 0.952, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DAO and L3HYPDH DAO interacts directly with L3HYPDH with a confidence score of 0.943, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ALAS1 and DAO ALAS1 interacts directly with DAO with a confidence score of 0.918, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DCTN1 and DCTN6 DCTN1 interacts directly with DCTN6 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between DCTN1 and DCTN5 DCTN1 interacts directly with DCTN5 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ACTR10 and DCTN1 ACTR10 interacts directly with DCTN1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between DCTN1 and DCTN2 DCTN1 interacts directly with DCTN2 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between CLIP1 and DCTN1 CLIP1 interacts directly with DCTN1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between DCTN1 and DYNC1H1 DCTN1 interacts directly with DYNC1H1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ACTR1A and DCTN1 ACTR1A interacts directly with DCTN1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between DCTN1 and DCTN3 DCTN1 interacts directly with DCTN3 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between DCTN1 and DCTN4 DCTN1 interacts directly with DCTN4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between BICD2 and DCTN1 BICD2 interacts directly with DCTN1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ELP3 and ELP4 ELP3 interacts directly with ELP4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP3 and ELP5 ELP3 interacts directly with ELP5 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP1 and ELP3 ELP1 interacts directly with ELP3 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP2 and ELP3 ELP2 interacts directly with ELP3 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP3 and ELP6 ELP3 interacts directly with ELP6 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DPH3 and ELP3 DPH3 interacts directly with ELP3 with a confidence score of 0.927, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP3 and KTI12 ELP3 interacts directly with KTI12 with a confidence score of 0.926, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CTU1 and ELP3 CTU1 interacts directly with ELP3 with a confidence score of 0.926, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELP3 and KAT2A ELP3 interacts directly with KAT2A with a confidence score of 0.843, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between ELP3 and KAT2B ELP3 interacts directly with KAT2B with a confidence score of 0.834, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between ERBB3 and ERBB4 ERBB3 interacts directly with ERBB4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and SHC1 ERBB4 interacts directly with SHC1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between BTC and ERBB4 BTC interacts directly with ERBB4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and NRG3 ERBB4 interacts directly with NRG3 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and NRG2 ERBB4 interacts directly with NRG2 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and GRB2 ERBB4 interacts directly with GRB2 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between EGF and ERBB4 EGF interacts directly with ERBB4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and EREG ERBB4 interacts directly with EREG with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and HBEGF ERBB4 interacts directly with HBEGF with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ERBB4 and NRG1 ERBB4 interacts directly with NRG1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FGGY and SHPK FGGY interacts directly with SHPK with a confidence score of 0.879, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FGGY and GPD2 FGGY interacts directly with GPD2 with a confidence score of 0.786, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CTNS and FGGY CTNS interacts directly with FGGY with a confidence score of 0.719, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ELP3 and FGGY ELP3 interacts directly with FGGY with a confidence score of 0.703, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and PIKFYVE FIG4 interacts directly with PIKFYVE with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and VAC14 FIG4 interacts directly with VAC14 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTMR2 FIG4 interacts directly with MTMR2 with a confidence score of 0.976, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTM1 FIG4 interacts directly with MTM1 with a confidence score of 0.959, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and PIK3C3 FIG4 interacts directly with PIK3C3 with a confidence score of 0.951, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTMR1 FIG4 interacts directly with MTMR1 with a confidence score of 0.943, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTMR14 FIG4 interacts directly with MTMR14 with a confidence score of 0.937, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTMR6 FIG4 interacts directly with MTMR6 with a confidence score of 0.936, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and INPP4A FIG4 interacts directly with INPP4A with a confidence score of 0.934, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FIG4 and MTMR7 FIG4 interacts directly with MTMR7 with a confidence score of 0.933, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FUS and TARDBP FUS interacts directly with TARDBP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FUS and TNPO1 FUS interacts directly with TNPO1 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and SOD1 FUS interacts directly with SOD1 with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between DROSHA and FUS DROSHA interacts directly with FUS with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and HNRNPA2B1 FUS interacts directly with HNRNPA2B1 with a confidence score of 0.99, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ENSP00000478249 and FUS ENSP00000478249 interacts directly with FUS with a confidence score of 0.987, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and SFPQ FUS interacts directly with SFPQ with a confidence score of 0.985, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and SRSF10 FUS interacts directly with SRSF10 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and ILF3 FUS interacts directly with ILF3 with a confidence score of 0.982, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FUS and HNRNPC FUS interacts directly with HNRNPC with a confidence score of 0.976, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPC HNRNPA1 interacts directly with HNRNPC with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and TNPO1 HNRNPA1 interacts directly with TNPO1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPH1 HNRNPA1 interacts directly with HNRNPH1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPA2B1 HNRNPA1 interacts directly with HNRNPA2B1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and PTBP1 HNRNPA1 interacts directly with PTBP1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and TARDBP HNRNPA1 interacts directly with TARDBP with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPK HNRNPA1 interacts directly with HNRNPK with a confidence score of 0.995, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPL HNRNPA1 interacts directly with HNRNPL with a confidence score of 0.993, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and SRSF1 HNRNPA1 interacts directly with SRSF1 with a confidence score of 0.993, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HNRNPA1 and HNRNPM HNRNPA1 interacts directly with HNRNPM with a confidence score of 0.993, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KLC2 KIF5A interacts directly with KLC2 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KLC1 KIF5A interacts directly with KLC1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KLC4 KIF5A interacts directly with KLC4 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KLC3 KIF5A interacts directly with KLC3 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KIF5B KIF5A interacts directly with KIF5B with a confidence score of 0.97, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and KIF5C KIF5A interacts directly with KIF5C with a confidence score of 0.965, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and NEFL KIF5A interacts directly with NEFL with a confidence score of 0.95, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and NEFH KIF5A interacts directly with NEFH with a confidence score of 0.947, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between KIF5A and NEFM KIF5A interacts directly with NEFM with a confidence score of 0.936, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KIF5A and SNCA KIF5A interacts directly with SNCA with a confidence score of 0.924, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between LRP12 and NOTCH2NLC LRP12 interacts directly with NOTCH2NLC with a confidence score of 0.722, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MATR3 and TARDBP MATR3 interacts directly with TARDBP with a confidence score of 0.995, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MATR3 and NONO MATR3 interacts directly with NONO with a confidence score of 0.993, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MATR3 and SFPQ MATR3 interacts directly with SFPQ with a confidence score of 0.974, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPA1 and MATR3 HNRNPA1 interacts directly with MATR3 with a confidence score of 0.95, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MATR3 and RBM14 MATR3 interacts directly with RBM14 with a confidence score of 0.949, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPC and MATR3 HNRNPC interacts directly with MATR3 with a confidence score of 0.946, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPM and MATR3 HNRNPM interacts directly with MATR3 with a confidence score of 0.928, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MATR3 and PSPC1 MATR3 interacts directly with PSPC1 with a confidence score of 0.923, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPK and MATR3 HNRNPK interacts directly with MATR3 with a confidence score of 0.923, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPH1 and MATR3 HNRNPH1 interacts directly with MATR3 with a confidence score of 0.911, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MOBP and MOG MOBP interacts directly with MOG with a confidence score of 0.897, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MOBP and PLP1 MOBP interacts directly with PLP1 with a confidence score of 0.831, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MOBP and OPALIN MOBP interacts directly with OPALIN with a confidence score of 0.793, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MECP2 and MOBP MECP2 interacts directly with MOBP with a confidence score of 0.785, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between ERMN and MOBP ERMN interacts directly with MOBP with a confidence score of 0.785, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MAG and MOBP MAG interacts directly with MOBP with a confidence score of 0.763, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MBP and MOBP MBP interacts directly with MOBP with a confidence score of 0.754, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between CNP and MOBP CNP interacts directly with MOBP with a confidence score of 0.741, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between NEFH and NEFL NEFH interacts directly with NEFL with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between NEFH and NEFM NEFH interacts directly with NEFM with a confidence score of 0.993, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between INA and NEFH INA interacts directly with NEFH with a confidence score of 0.988, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KIF5C and NEFH KIF5C interacts directly with NEFH with a confidence score of 0.926, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KLC1 and NEFH KLC1 interacts directly with NEFH with a confidence score of 0.923, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KLC2 and NEFH KLC2 interacts directly with NEFH with a confidence score of 0.922, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KLC3 and NEFH KLC3 interacts directly with NEFH with a confidence score of 0.919, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KIF5B and NEFH KIF5B interacts directly with NEFH with a confidence score of 0.918, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between KLC4 and NEFH KLC4 interacts directly with NEFH with a confidence score of 0.915, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DYNC2H1 and NEK1 DYNC2H1 interacts directly with NEK1 with a confidence score of 0.972, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between KIF3A and NEK1 KIF3A interacts directly with NEK1 with a confidence score of 0.802, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CHCHD10 and NEK1 CHCHD10 interacts directly with NEK1 with a confidence score of 0.733, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NEK1 and VAPB NEK1 interacts directly with VAPB with a confidence score of 0.717, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and TBK1 OPTN interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and RAB8A OPTN interacts directly with RAB8A with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAP and OPTN GABARAP interacts directly with OPTN with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAPL1 and OPTN GABARAPL1 interacts directly with OPTN with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAPL2 and OPTN GABARAPL2 interacts directly with OPTN with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MAP1LC3B and OPTN MAP1LC3B interacts directly with OPTN with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between HTT and OPTN HTT interacts directly with OPTN with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and UBC OPTN interacts directly with UBC with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and SQSTM1 OPTN interacts directly with SQSTM1 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and RAB11A OPTN interacts directly with RAB11A with a confidence score of 0.993, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PFN1 and VASP PFN1 interacts directly with VASP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ACTB and PFN1 ACTB interacts directly with PFN1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between CFL1 and PFN1 CFL1 interacts directly with PFN1 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between APBB1IP and PFN1 APBB1IP interacts directly with PFN1 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between PFN1 and XPO6 PFN1 interacts directly with XPO6 with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ACTG1 and PFN1 ACTG1 interacts directly with PFN1 with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between PFN1 and WAS PFN1 interacts directly with WAS with a confidence score of 0.991, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between PFN1 and VCL PFN1 interacts directly with VCL with a confidence score of 0.978, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ACTA1 and PFN1 ACTA1 interacts directly with PFN1 with a confidence score of 0.976, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between DIAPH1 and PFN1 DIAPH1 interacts directly with PFN1 with a confidence score of 0.97, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between NEFM and PRPH NEFM interacts directly with PRPH with a confidence score of 0.904, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NEFH and PRPH NEFH interacts directly with PRPH with a confidence score of 0.904, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NEFL and PRPH NEFL interacts directly with PRPH with a confidence score of 0.902, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GOSR1 and SCFD1 GOSR1 interacts directly with SCFD1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between BET1 and SCFD1 BET1 interacts directly with SCFD1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SCFD1 and STX5 SCFD1 interacts directly with STX5 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between GOSR2 and SCFD1 GOSR2 interacts directly with SCFD1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SCFD1 and STX18 SCFD1 interacts directly with STX18 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SCFD1 and SEC22B SCFD1 interacts directly with SEC22B with a confidence score of 0.997, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SCFD1 and YKT6 SCFD1 interacts directly with YKT6 with a confidence score of 0.995, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between NAPA and SCFD1 NAPA interacts directly with SCFD1 with a confidence score of 0.984, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SCFD1 and USO1 SCFD1 interacts directly with USO1 with a confidence score of 0.97, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between NSF and SCFD1 NSF interacts directly with SCFD1 with a confidence score of 0.968, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between BRCA1 and SETX BRCA1 interacts directly with SETX with a confidence score of 0.99, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NRDC and SETX NRDC interacts directly with SETX with a confidence score of 0.956, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SCAF8 and SETX SCAF8 interacts directly with SETX with a confidence score of 0.948, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between APTX and SETX APTX interacts directly with SETX with a confidence score of 0.945, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between POLR2A and SETX POLR2A interacts directly with SETX with a confidence score of 0.93, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SCAF4 and SETX SCAF4 interacts directly with SETX with a confidence score of 0.926, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between FUS and SETX FUS interacts directly with SETX with a confidence score of 0.887, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SETX and XRN2 SETX interacts directly with XRN2 with a confidence score of 0.874, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SETX and VAPB SETX interacts directly with VAPB with a confidence score of 0.865, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between HSPA5 and SIGMAR1 HSPA5 interacts directly with SIGMAR1 with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between CYP51A1 and SIGMAR1 CYP51A1 interacts directly with SIGMAR1 with a confidence score of 0.985, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ERG28 and SIGMAR1 ERG28 interacts directly with SIGMAR1 with a confidence score of 0.983, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SIGMAR1 and SQLE SIGMAR1 interacts directly with SQLE with a confidence score of 0.974, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KCNH6 and SIGMAR1 KCNH6 interacts directly with SIGMAR1 with a confidence score of 0.944, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SIGMAR1 and TMEM97 SIGMAR1 interacts directly with TMEM97 with a confidence score of 0.943, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ITPR1 and SIGMAR1 ITPR1 interacts directly with SIGMAR1 with a confidence score of 0.938, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between ITPR3 and SIGMAR1 ITPR3 interacts directly with SIGMAR1 with a confidence score of 0.934, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between KCNA4 and SIGMAR1 KCNA4 interacts directly with SIGMAR1 with a confidence score of 0.917, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between MSMO1 and SIGMAR1 MSMO1 interacts directly with SIGMAR1 with a confidence score of 0.893, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between CCS and SOD1 CCS interacts directly with SOD1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between BCL2 and SOD1 BCL2 interacts directly with SOD1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between PARK7 and SOD1 PARK7 interacts directly with SOD1 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SOD1 and VDAC1 SOD1 interacts directly with VDAC1 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SOD1 and SOD2 SOD1 interacts directly with SOD2 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SOD1 and TARDBP SOD1 interacts directly with TARDBP with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NEFL and SOD1 NEFL interacts directly with SOD1 with a confidence score of 0.976, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between HSPA5 and SOD1 HSPA5 interacts directly with SOD1 with a confidence score of 0.975, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between DERL1 and SOD1 DERL1 interacts directly with SOD1 with a confidence score of 0.964, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between AP5Z1 and SPG11 AP5Z1 interacts directly with SPG11 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPG11 and ZFYVE26 SPG11 interacts directly with ZFYVE26 with a confidence score of 0.99, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between AP5B1 and SPG11 AP5B1 interacts directly with SPG11 with a confidence score of 0.98, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between AP5S1 and SPG11 AP5S1 interacts directly with SPG11 with a confidence score of 0.961, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPG11 and SPG7 SPG11 interacts directly with SPG7 with a confidence score of 0.957, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPG11 and SPG21 SPG11 interacts directly with SPG21 with a confidence score of 0.949, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPAST and SPG11 SPAST interacts directly with SPG11 with a confidence score of 0.936, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PNPLA6 and SPG11 PNPLA6 interacts directly with SPG11 with a confidence score of 0.856, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPART and SPG11 SPART interacts directly with SPG11 with a confidence score of 0.852, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between AP5M1 and SPG11 AP5M1 interacts directly with SPG11 with a confidence score of 0.838, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SPTLC1 and SPTLC2 SPTLC1 interacts directly with SPTLC2 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between SPTLC1 and SPTSSA SPTLC1 interacts directly with SPTSSA with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ORMDL3 and SPTLC1 ORMDL3 interacts directly with SPTLC1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between SPTLC1 and SPTSSB SPTLC1 interacts directly with SPTSSB with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between SPTLC1 and SPTLC3 SPTLC1 interacts directly with SPTLC3 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between KDSR and SPTLC1 KDSR interacts directly with SPTLC1 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ORMDL1 and SPTLC1 ORMDL1 interacts directly with SPTLC1 with a confidence score of 0.972, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ORMDL2 and SPTLC1 ORMDL2 interacts directly with SPTLC1 with a confidence score of 0.969, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between ORM1 and SPTLC1 ORM1 interacts directly with SPTLC1 with a confidence score of 0.943, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between SPTLC1 and ZDHHC9 SPTLC1 interacts directly with ZDHHC9 with a confidence score of 0.91, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between MAP1LC3A and SQSTM1 MAP1LC3A interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between KEAP1 and SQSTM1 KEAP1 interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between NBR1 and SQSTM1 NBR1 interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAP and SQSTM1 GABARAP interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MAP1LC3B and SQSTM1 MAP1LC3B interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAPL2 and SQSTM1 GABARAPL2 interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SQSTM1 and TRAF6 SQSTM1 interacts directly with TRAF6 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SQSTM1 and UBC SQSTM1 interacts directly with UBC with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between GABARAPL1 and SQSTM1 GABARAPL1 interacts directly with SQSTM1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between RIPK1 and SQSTM1 RIPK1 interacts directly with SQSTM1 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TAF15 and TBP TAF15 interacts directly with TBP with a confidence score of 0.938, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TAF13 and TAF15 TAF13 interacts directly with TAF15 with a confidence score of 0.923, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between HNRNPA1 and TAF15 HNRNPA1 interacts directly with TAF15 with a confidence score of 0.886, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TAF15 and TARDBP TAF15 interacts directly with TARDBP with a confidence score of 0.884, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TAF15 and TAF5 TAF15 interacts directly with TAF5 with a confidence score of 0.883, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TAF15 and TAF4 TAF15 interacts directly with TAF4 with a confidence score of 0.874, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between MATR3-2 and TAF15 MATR3-2 interacts directly with TAF15 with a confidence score of 0.872, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between NR4A3 and TAF15 NR4A3 interacts directly with TAF15 with a confidence score of 0.865, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TAF11 and TAF15 TAF11 interacts directly with TAF15 with a confidence score of 0.86, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TAF15 and TAF2 TAF15 interacts directly with TAF2 with a confidence score of 0.858, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between HNRNPA2B1 and TARDBP HNRNPA2B1 interacts directly with TARDBP with a confidence score of 0.998, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MATR3-2 and TARDBP MATR3-2 interacts directly with TARDBP with a confidence score of 0.996, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between SNCA and TARDBP SNCA interacts directly with TARDBP with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between DROSHA and TARDBP DROSHA interacts directly with TARDBP with a confidence score of 0.992, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PRKN and TARDBP PRKN interacts directly with TARDBP with a confidence score of 0.984, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between IRF3 and TBK1 IRF3 interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TANK and TBK1 TANK interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TBK1 and TBKBP1 TBK1 interacts directly with TBKBP1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between IKBKE and TBK1 IKBKE interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between STING1 and TBK1 STING1 interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between DDX3X and TBK1 DDX3X interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between AZI2 and TBK1 AZI2 interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TBK1 and TRAF3 TBK1 interacts directly with TRAF3 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MAVS and TBK1 MAVS interacts directly with TBK1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between G3BP1 and TIA1 G3BP1 interacts directly with TIA1 with a confidence score of 0.998, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TIA1 and TIAL1 TIA1 interacts directly with TIAL1 with a confidence score of 0.983, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between SNRPC and TIA1 SNRPC interacts directly with TIA1 with a confidence score of 0.976, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ELAVL1 and TIA1 ELAVL1 interacts directly with TIA1 with a confidence score of 0.975, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between EIF4G1 and TIA1 EIF4G1 interacts directly with TIA1 with a confidence score of 0.966, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between EIF4E and TIA1 EIF4E interacts directly with TIA1 with a confidence score of 0.938, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PABPC1 and TIA1 PABPC1 interacts directly with TIA1 with a confidence score of 0.934, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TARDBP and TIA1 TARDBP interacts directly with TIA1 with a confidence score of 0.927, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PCBP2 and TIA1 PCBP2 interacts directly with TIA1 with a confidence score of 0.904, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between ATXN2 and TIA1 ATXN2 interacts directly with TIA1 with a confidence score of 0.895, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TARDBP and TMEM106B TARDBP interacts directly with TMEM106B with a confidence score of 0.935, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between GRN and TMEM106B GRN interacts directly with TMEM106B with a confidence score of 0.906, suggesting functional coregulation or shared cascade. High protective hypothesis Network-proximity association between CHMP2B and TMEM106B CHMP2B interacts directly with TMEM106B with a confidence score of 0.802, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between MAP6 and TMEM106B MAP6 interacts directly with TMEM106B with a confidence score of 0.797, suggesting functional coregulation or shared cascade. Medium protective hypothesis Network-proximity association between C9orf72 and TMEM106B C9orf72 interacts directly with TMEM106B with a confidence score of 0.753, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between MAPT and TMEM106B MAPT interacts directly with TMEM106B with a confidence score of 0.749, suggesting functional coregulation or shared cascade. Medium protective hypothesis Network-proximity association between TRPM7 and TRPV2 TRPM7 interacts directly with TRPV2 with a confidence score of 0.978, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TRPM6 and TRPM7 TRPM6 interacts directly with TRPM7 with a confidence score of 0.974, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between MLKL and TRPM7 MLKL interacts directly with TRPM7 with a confidence score of 0.932, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TRPM2 and TRPM7 TRPM2 interacts directly with TRPM7 with a confidence score of 0.924, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between TRPC1 and TRPM7 TRPC1 interacts directly with TRPM7 with a confidence score of 0.814, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between PLCB1 and TRPM7 PLCB1 interacts directly with TRPM7 with a confidence score of 0.792, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between SLC41A1 and TRPM7 SLC41A1 interacts directly with TRPM7 with a confidence score of 0.78, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TRPM7 and TRPV4 TRPM7 interacts directly with TRPV4 with a confidence score of 0.754, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TRPA1 and TRPM7 TRPA1 interacts directly with TRPM7 with a confidence score of 0.751, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TRPM7 and TRPV6 TRPM7 interacts directly with TRPV6 with a confidence score of 0.747, suggesting functional coregulation or shared cascade. Medium candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB2A TUBA4A interacts directly with TUBB2A with a confidence score of 0.995, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB TUBA4A interacts directly with TUBB with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB3 TUBA4A interacts directly with TUBB3 with a confidence score of 0.993, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB4B TUBA4A interacts directly with TUBB4B with a confidence score of 0.991, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB4A TUBA4A interacts directly with TUBB4A with a confidence score of 0.983, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between MAPT and TUBA4A MAPT interacts directly with TUBA4A with a confidence score of 0.981, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB6 TUBA4A interacts directly with TUBB6 with a confidence score of 0.969, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB2B TUBA4A interacts directly with TUBB2B with a confidence score of 0.968, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB1 TUBA4A interacts directly with TUBB1 with a confidence score of 0.964, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TUBA4A and TUBB8 TUBA4A interacts directly with TUBB8 with a confidence score of 0.963, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between UBC and UBQLN2 UBC interacts directly with UBQLN2 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between DESI1 and UBQLN2 DESI1 interacts directly with UBQLN2 with a confidence score of 0.994, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between HSPA13 and UBQLN2 HSPA13 interacts directly with UBQLN2 with a confidence score of 0.99, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between RPS27A and UBQLN2 RPS27A interacts directly with UBQLN2 with a confidence score of 0.988, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ADRM1 and UBQLN2 ADRM1 interacts directly with UBQLN2 with a confidence score of 0.982, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PSMD4 and UBQLN2 PSMD4 interacts directly with UBQLN2 with a confidence score of 0.981, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between UBB and UBQLN2 UBB interacts directly with UBQLN2 with a confidence score of 0.979, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between UBA52 and UBQLN2 UBA52 interacts directly with UBQLN2 with a confidence score of 0.978, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between TARDBP and UBQLN2 TARDBP interacts directly with UBQLN2 with a confidence score of 0.968, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OPTN and UBQLN2 OPTN interacts directly with UBQLN2 with a confidence score of 0.954, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PSMD4 and UBQLN4 PSMD4 interacts directly with UBQLN4 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD14 and UBQLN4 PSMD14 interacts directly with UBQLN4 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between DESI1 and UBQLN4 DESI1 interacts directly with UBQLN4 with a confidence score of 0.997, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD1 and UBQLN4 PSMD1 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD8 and UBQLN4 PSMD8 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD12 and UBQLN4 PSMD12 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD13 and UBQLN4 PSMD13 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD6 and UBQLN4 PSMD6 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMD11 and UBQLN4 PSMD11 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between PSMC2 and UBQLN4 PSMC2 interacts directly with UBQLN4 with a confidence score of 0.996, suggesting functional coregulation or shared cascade. High candidate mechanism hypothesis Network-proximity association between CALM3 and UNC13A CALM3 interacts directly with UNC13A with a confidence score of 0.991, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between RIMS2 and UNC13A RIMS2 interacts directly with UNC13A with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between RIMS1 and UNC13A RIMS1 interacts directly with UNC13A with a confidence score of 0.98, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALM2 and UNC13A CALM2 interacts directly with UNC13A with a confidence score of 0.914, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALM1 and UNC13A CALM1 interacts directly with UNC13A with a confidence score of 0.911, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALML5 and UNC13A CALML5 interacts directly with UNC13A with a confidence score of 0.911, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALML3 and UNC13A CALML3 interacts directly with UNC13A with a confidence score of 0.911, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between UNC13A and UNC13C UNC13A interacts directly with UNC13C with a confidence score of 0.909, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALML4 and UNC13A CALML4 interacts directly with UNC13A with a confidence score of 0.905, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CALML6 and UNC13A CALML6 interacts directly with UNC13A with a confidence score of 0.905, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between RMDN3 and VAPB RMDN3 interacts directly with VAPB with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ACBD5 and VAPB ACBD5 interacts directly with VAPB with a confidence score of 0.997, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ATF6 and VAPB ATF6 interacts directly with VAPB with a confidence score of 0.989, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ACBD4 and VAPB ACBD4 interacts directly with VAPB with a confidence score of 0.98, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OSBP and VAPB OSBP interacts directly with VAPB with a confidence score of 0.967, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between VAPA and VAPB VAPA interacts directly with VAPB with a confidence score of 0.964, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between OSBPL9 and VAPB OSBPL9 interacts directly with VAPB with a confidence score of 0.964, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between PITPNM1 and VAPB PITPNM1 interacts directly with VAPB with a confidence score of 0.948, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between STARD3 and VAPB STARD3 interacts directly with VAPB with a confidence score of 0.94, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between CERT1 and VAPB CERT1 interacts directly with VAPB with a confidence score of 0.93, suggesting functional coregulation or shared cascade. Low candidate mechanism hypothesis Network-proximity association between ATXN3 and VCP ATXN3 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between VCP and VCPIP1 VCP interacts directly with VCPIP1 with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between SELENOS and VCP SELENOS interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FAF1 and VCP FAF1 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between DERL1 and VCP DERL1 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between FAF2 and VCP FAF2 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between NPLOC4 and VCP NPLOC4 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between UFD1 and VCP UFD1 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between UBXN6 and VCP UBXN6 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Network-proximity association between UBXN1 and VCP UBXN1 interacts directly with VCP with a confidence score of 0.999, suggesting functional coregulation or shared cascade. Low protective hypothesis Variant and pathway convergence of OPTN in Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Gene OPTN contains pathogenic variants and belongs to pathway Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (R-HSA-936964) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Recruitment of mitotic centrosome proteins and complexes Gene TUBA4A contains pathogenic variants and belongs to pathway Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of SQSTM1 in PINK1-PRKN Mediated Mitophagy Gene SQSTM1 contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Platelet degranulation Gene TUBA4A contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene SOD1. Low candidate mechanism hypothesis Variant and pathway convergence of KIF5A in COPI-dependent Golgi-to-ER retrograde traffic Gene KIF5A contains pathogenic variants and belongs to pathway COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in AURKA Activation by TPX2 Gene TUBA4A contains pathogenic variants and belongs to pathway AURKA Activation by TPX2 (R-HSA-8854518) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TBK1 in Potential therapeutics for SARS Gene TBK1 contains pathogenic variants and belongs to pathway Potential therapeutics for SARS (R-HSA-9679191) which is shared with the ALS seed gene SIGMAR1. Low protective hypothesis Variant and pathway convergence of SOD1 in Platelet degranulation Gene SOD1 contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in Regulation of TNFR1 signaling Gene TBK1 contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in MHC class II antigen presentation Gene TUBA4A contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TUBA4A in Recruitment of NuMA to mitotic centrosomes Gene TUBA4A contains pathogenic variants and belongs to pathway Recruitment of NuMA to mitotic centrosomes (R-HSA-380320) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of FUS in Processing of Capped Intron-Containing Pre-mRNA Gene FUS contains pathogenic variants and belongs to pathway Processing of Capped Intron-Containing Pre-mRNA (R-HSA-72203) which is shared with the ALS seed gene HNRNPA1. Low protective hypothesis Variant and pathway convergence of TUBA4A in Aggrephagy Gene TUBA4A contains pathogenic variants and belongs to pathway Aggrephagy (R-HSA-9646399) which is shared with the ALS seed gene VCP. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in TNFR1-induced proapoptotic signaling Gene TBK1 contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of HNRNPA1 in mRNA Splicing - Major Pathway Gene HNRNPA1 contains pathogenic variants and belongs to pathway mRNA Splicing - Major Pathway (R-HSA-72163) which is shared with the ALS seed gene FUS. Low protective hypothesis Variant and pathway convergence of CCNF in Neddylation Gene CCNF contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene SQSTM1. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Sealing of the nuclear envelope (NE) by ESCRT-III Gene TUBA4A contains pathogenic variants and belongs to pathway Sealing of the nuclear envelope (NE) by ESCRT-III (R-HSA-9668328) which is shared with the ALS seed gene CHMP2B. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Regulation of PLK1 Activity at G2/M Transition Gene DCTN1 contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene OPTN. Low protective hypothesis Variant and pathway convergence of CYLD in Regulation of TNFR1 signaling Gene CYLD contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Gene DCTN1 contains pathogenic variants and belongs to pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (R-HSA-3371497) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of TUBA4A in COPI-mediated anterograde transport Gene TUBA4A contains pathogenic variants and belongs to pathway COPI-mediated anterograde transport (R-HSA-6807878) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of SQSTM1 in Signaling by ALK fusions and activated point mutants Gene SQSTM1 contains pathogenic variants and belongs to pathway Signaling by ALK fusions and activated point mutants (R-HSA-9725370) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of FUS in Dengue Virus-Host Interactions Gene FUS contains pathogenic variants and belongs to pathway Dengue Virus-Host Interactions (R-HSA-9918481) which is shared with the ALS seed gene HNRNPA1. Low protective hypothesis Variant and pathway convergence of OPTN in TNFR1-induced NF-kappa-B signaling pathway Gene OPTN contains pathogenic variants and belongs to pathway TNFR1-induced NF-kappa-B signaling pathway (R-HSA-5357956) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in MHC class II antigen presentation Gene DCTN1 contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of CYLD in TNFR1-induced NF-kappa-B signaling pathway Gene CYLD contains pathogenic variants and belongs to pathway TNFR1-induced NF-kappa-B signaling pathway (R-HSA-5357956) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in Negative regulators of DDX58/IFIH1 signaling Gene TBK1 contains pathogenic variants and belongs to pathway Negative regulators of DDX58/IFIH1 signaling (R-HSA-936440) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in Regulation of TNFR1 signaling Gene OPTN contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Regulation of PLK1 Activity at G2/M Transition Gene DCTN1 contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of DCTN1 in Loss of proteins required for interphase microtubule organization from the centrosome Gene DCTN1 contains pathogenic variants and belongs to pathway Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of DCTN1 in Anchoring of the basal body to the plasma membrane Gene DCTN1 contains pathogenic variants and belongs to pathway Anchoring of the basal body to the plasma membrane (R-HSA-5620912) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of FUS in mRNA Polyadenylation Gene FUS contains pathogenic variants and belongs to pathway mRNA Polyadenylation (R-HSA-9770562) which is shared with the ALS seed gene HNRNPA1. Low protective hypothesis Variant and pathway convergence of TBK1 in Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Gene TBK1 contains pathogenic variants and belongs to pathway Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (R-HSA-9824878) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of SQSTM1 in Neddylation Gene SQSTM1 contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene VCP. Low candidate mechanism hypothesis Variant and pathway convergence of KIF5A in MHC class II antigen presentation Gene KIF5A contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of CYLD in Negative regulators of DDX58/IFIH1 signaling Gene CYLD contains pathogenic variants and belongs to pathway Negative regulators of DDX58/IFIH1 signaling (R-HSA-936440) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Recruitment of NuMA to mitotic centrosomes Gene DCTN1 contains pathogenic variants and belongs to pathway Recruitment of NuMA to mitotic centrosomes (R-HSA-380320) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of DCTN1 in AURKA Activation by TPX2 Gene DCTN1 contains pathogenic variants and belongs to pathway AURKA Activation by TPX2 (R-HSA-8854518) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of HNRNPA1 in Processing of Capped Intron-Containing Pre-mRNA Gene HNRNPA1 contains pathogenic variants and belongs to pathway Processing of Capped Intron-Containing Pre-mRNA (R-HSA-72203) which is shared with the ALS seed gene FUS. Low protective hypothesis Variant and pathway convergence of PFN1 in Platelet degranulation Gene PFN1 contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of SQSTM1 in KEAP1-NFE2L2 pathway Gene SQSTM1 contains pathogenic variants and belongs to pathway KEAP1-NFE2L2 pathway (R-HSA-9755511) which is shared with the ALS seed gene VCP. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Loss of Nlp from mitotic centrosomes Gene TUBA4A contains pathogenic variants and belongs to pathway Loss of Nlp from mitotic centrosomes (R-HSA-380259) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TUBA4A in COPI-independent Golgi-to-ER retrograde traffic Gene TUBA4A contains pathogenic variants and belongs to pathway COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TBK1 in TICAM1-dependent activation of IRF3/IRF7 Gene TBK1 contains pathogenic variants and belongs to pathway TICAM1-dependent activation of IRF3/IRF7 (R-HSA-9013973) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in RHO GTPases Activate Formins Gene TUBA4A contains pathogenic variants and belongs to pathway RHO GTPases Activate Formins (R-HSA-5663220) which is shared with the ALS seed gene PFN1. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in PINK1-PRKN Mediated Mitophagy Gene TBK1 contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Recruitment of mitotic centrosome proteins and complexes Gene DCTN1 contains pathogenic variants and belongs to pathway Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of OPTN in Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Gene OPTN contains pathogenic variants and belongs to pathway Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (R-HSA-9824878) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of SIGMAR1 in Potential therapeutics for SARS Gene SIGMAR1 contains pathogenic variants and belongs to pathway Potential therapeutics for SARS (R-HSA-9679191) which is shared with the ALS seed gene TBK1. Low protective hypothesis Variant and pathway convergence of SPTLC1 in Sphingolipid de novo biosynthesis Gene SPTLC1 contains pathogenic variants and belongs to pathway Sphingolipid de novo biosynthesis (R-HSA-1660661) which is shared with the ALS seed gene VAPB. Low protective hypothesis Variant and pathway convergence of FUS in mRNA Splicing - Major Pathway Gene FUS contains pathogenic variants and belongs to pathway mRNA Splicing - Major Pathway (R-HSA-72163) which is shared with the ALS seed gene HNRNPA1. Low protective hypothesis Variant and pathway convergence of CYLD in TNFR1-induced proapoptotic signaling Gene CYLD contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in MHC class II antigen presentation Gene TUBA4A contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene KIF5A. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Regulation of PLK1 Activity at G2/M Transition Gene TUBA4A contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Regulation of PLK1 Activity at G2/M Transition Gene TUBA4A contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of OPTN in PINK1-PRKN Mediated Mitophagy Gene OPTN contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Gene OPTN contains pathogenic variants and belongs to pathway Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (R-HSA-9828211) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Gene TUBA4A contains pathogenic variants and belongs to pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (R-HSA-3371497) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TBK1 in Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Gene TBK1 contains pathogenic variants and belongs to pathway Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (R-HSA-936964) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Signaling by ALK fusions and activated point mutants Gene DCTN1 contains pathogenic variants and belongs to pathway Signaling by ALK fusions and activated point mutants (R-HSA-9725370) which is shared with the ALS seed gene SQSTM1. Low protective hypothesis Variant and pathway convergence of OPTN in TICAM1-dependent activation of IRF3/IRF7 Gene OPTN contains pathogenic variants and belongs to pathway TICAM1-dependent activation of IRF3/IRF7 (R-HSA-9013973) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of VCP in Aggrephagy Gene VCP contains pathogenic variants and belongs to pathway Aggrephagy (R-HSA-9646399) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Loss of proteins required for interphase microtubule organization from the centrosome Gene TUBA4A contains pathogenic variants and belongs to pathway Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of SOD1 in Platelet degranulation Gene SOD1 contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene PFN1. Low protective hypothesis Variant and pathway convergence of HNRNPA1 in mRNA Polyadenylation Gene HNRNPA1 contains pathogenic variants and belongs to pathway mRNA Polyadenylation (R-HSA-9770562) which is shared with the ALS seed gene FUS. Low protective hypothesis Variant and pathway convergence of HNRNPA1 in Dengue Virus-Host Interactions Gene HNRNPA1 contains pathogenic variants and belongs to pathway Dengue Virus-Host Interactions (R-HSA-9918481) which is shared with the ALS seed gene FUS. Low protective hypothesis Variant and pathway convergence of OPTN in Regulation of TNFR1 signaling Gene OPTN contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of VCP in Neddylation Gene VCP contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene SQSTM1. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in TNFR1-induced proapoptotic signaling Gene TBK1 contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Kinesins Gene TUBA4A contains pathogenic variants and belongs to pathway Kinesins (R-HSA-983189) which is shared with the ALS seed gene KIF5A. Low candidate mechanism hypothesis Variant and pathway convergence of VCP in KEAP1-NFE2L2 pathway Gene VCP contains pathogenic variants and belongs to pathway KEAP1-NFE2L2 pathway (R-HSA-9755511) which is shared with the ALS seed gene SQSTM1. Low candidate mechanism hypothesis Variant and pathway convergence of TBK1 in PINK1-PRKN Mediated Mitophagy Gene TBK1 contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene SQSTM1. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in Platelet degranulation Gene TUBA4A contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene PFN1. Low candidate mechanism hypothesis Variant and pathway convergence of CHMP2B in Sealing of the nuclear envelope (NE) by ESCRT-III Gene CHMP2B contains pathogenic variants and belongs to pathway Sealing of the nuclear envelope (NE) by ESCRT-III (R-HSA-9668328) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in COPI-mediated anterograde transport Gene DCTN1 contains pathogenic variants and belongs to pathway COPI-mediated anterograde transport (R-HSA-6807878) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of DCTN1 in COPI-independent Golgi-to-ER retrograde traffic Gene DCTN1 contains pathogenic variants and belongs to pathway COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of HNRNPA1 in FGFR2 alternative splicing Gene HNRNPA1 contains pathogenic variants and belongs to pathway FGFR2 alternative splicing (R-HSA-6803529) which is shared with the ALS seed gene TIA1. Medium candidate mechanism hypothesis Variant and pathway convergence of KIF5A in Kinesins Gene KIF5A contains pathogenic variants and belongs to pathway Kinesins (R-HSA-983189) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of CYLD in Regulation of TNFR1 signaling Gene CYLD contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in Regulation of PLK1 Activity at G2/M Transition Gene OPTN contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of SQSTM1 in PINK1-PRKN Mediated Mitophagy Gene SQSTM1 contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in Loss of Nlp from mitotic centrosomes Gene DCTN1 contains pathogenic variants and belongs to pathway Loss of Nlp from mitotic centrosomes (R-HSA-380259) which is shared with the ALS seed gene TUBA4A. Low protective hypothesis Variant and pathway convergence of OPTN in TNFR1-induced proapoptotic signaling Gene OPTN contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of TUBA4A in COPI-dependent Golgi-to-ER retrograde traffic Gene TUBA4A contains pathogenic variants and belongs to pathway COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434) which is shared with the ALS seed gene KIF5A. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in PINK1-PRKN Mediated Mitophagy Gene OPTN contains pathogenic variants and belongs to pathway PINK1-PRKN Mediated Mitophagy (R-HSA-5205685) which is shared with the ALS seed gene SQSTM1. Low candidate mechanism hypothesis Variant and pathway convergence of PFN1 in Platelet degranulation Gene PFN1 contains pathogenic variants and belongs to pathway Platelet degranulation (R-HSA-114608) which is shared with the ALS seed gene SOD1. Low protective hypothesis Variant and pathway convergence of CYLD in TNFR1-induced proapoptotic signaling Gene CYLD contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in Regulation of PLK1 Activity at G2/M Transition Gene OPTN contains pathogenic variants and belongs to pathway Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of KIF5A in MHC class II antigen presentation Gene KIF5A contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TBK1 in Regulation of TNFR1 signaling Gene TBK1 contains pathogenic variants and belongs to pathway Regulation of TNFR1 signaling (R-HSA-5357905) which is shared with the ALS seed gene CYLD. Low candidate mechanism hypothesis Variant and pathway convergence of CCNF in Neddylation Gene CCNF contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene VCP. Low candidate mechanism hypothesis Variant and pathway convergence of OPTN in TNFR1-induced proapoptotic signaling Gene OPTN contains pathogenic variants and belongs to pathway TNFR1-induced proapoptotic signaling (R-HSA-5357786) which is shared with the ALS seed gene TBK1. Low candidate mechanism hypothesis Variant and pathway convergence of PFN1 in RHO GTPases Activate Formins Gene PFN1 contains pathogenic variants and belongs to pathway RHO GTPases Activate Formins (R-HSA-5663220) which is shared with the ALS seed gene TUBA4A. Low candidate mechanism hypothesis Variant and pathway convergence of DCTN1 in MHC class II antigen presentation Gene DCTN1 contains pathogenic variants and belongs to pathway MHC class II antigen presentation (R-HSA-2132295) which is shared with the ALS seed gene KIF5A. Low protective hypothesis Variant and pathway convergence of TUBA4A in Anchoring of the basal body to the plasma membrane Gene TUBA4A contains pathogenic variants and belongs to pathway Anchoring of the basal body to the plasma membrane (R-HSA-5620912) which is shared with the ALS seed gene DCTN1. Low protective hypothesis Variant and pathway convergence of TBK1 in Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Gene TBK1 contains pathogenic variants and belongs to pathway Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (R-HSA-9828211) which is shared with the ALS seed gene OPTN. Low candidate mechanism hypothesis Variant and pathway convergence of SQSTM1 in Neddylation Gene SQSTM1 contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene CCNF. Low candidate mechanism hypothesis Variant and pathway convergence of VCP in Neddylation Gene VCP contains pathogenic variants and belongs to pathway Neddylation (R-HSA-8951664) which is shared with the ALS seed gene CCNF. Low candidate mechanism interacts_with 0.98 interacts_with 0.997 interacts_with 0.976 interacts_with 0.999 interacts_with 0.992 interacts_with 0.999 interacts_with 0.999 interacts_with 0.982 interacts_with 0.964 interacts_with 0.952 interacts_with 0.918 has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.7415031239483322 associated_with_disease 0.5846605871686804 associated_with_disease 0.5671394000956553 associated_with_disease 0.455996525810445 associated_with_disease 0.049215717315512796 associated_with_disease 0.04531418598289128 associated_with_disease 0.04339606653707768 associated_with_disease 0.03984070833501085 associated_with_disease 0.03797802586739996 associated_with_disease 0.033720465941432194 associated_with_disease 0.032227363328505995 associated_with_disease 0.031857783473821295 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has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.6103425432677596 associated_with_disease 0.5660311237408793 associated_with_disease 0.21384464864024635 interacts_with 0.999 interacts_with 0.999 interacts_with 0.989 interacts_with 0.989 interacts_with 0.983 interacts_with 0.983 interacts_with 0.98 interacts_with 0.943 interacts_with 0.929 interacts_with 0.753 interacts_with 0.911 interacts_with 0.914 interacts_with 0.991 interacts_with 0.911 interacts_with 0.905 interacts_with 0.911 interacts_with 0.905 has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.7604554076163181 associated_with_disease 0.41839888299669586 associated_with_disease 0.00813075680306344 associated_with_disease 0.0050611907877655 participates_in_pathway participates_in_pathway interacts_with 0.999 interacts_with 0.986 interacts_with 0.984 interacts_with 0.946 interacts_with 0.918 interacts_with 0.917 interacts_with 0.911 interacts_with 0.91 interacts_with 0.893 interacts_with 0.999 interacts_with 0.93 has_variant associated_with_disease 0.5682101425267765 interacts_with 0.982 interacts_with 0.784 interacts_with 0.773 interacts_with 0.994 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has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.4088214044942417 associated_with_disease 0.03245650283841051 associated_with_disease 0.03134037167726271 associated_with_disease 0.0029566388374776143 associated_with_disease 0.0018478992734235094 associated_with_disease 0.0014783194187388072 participates_in_pathway interacts_with 0.985 interacts_with 0.985 interacts_with 0.979 interacts_with 0.978 interacts_with 0.888 interacts_with 0.875 interacts_with 0.816 interacts_with 0.736 interacts_with 0.733 interacts_with 0.996 interacts_with 0.994 interacts_with 0.987 has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.7726650520331655 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has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant has_variant associated_with_disease 0.6818540157543058 participates_in_pathway participates_in_pathway participates_in_pathway participates_in_pathway participates_in_pathway participates_in_pathway interacts_with 0.999 interacts_with 0.999 interacts_with 0.999 interacts_with 0.999 interacts_with 0.997 interacts_with 0.995 interacts_with 0.995 interacts_with 0.994 interacts_with 0.993 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